Resistance of Hepatitis C Virus to Inhibitors: Complexity and Clinical Implications

被引：36

作者：

Perales, Celia ^{[1
,2
,3
]}

Quer, Josep ^{[1
,3
,4
]}

Gregori, Josep ^{[1
,3
,5
]}

Esteban, Juan Ignacio ^{[1
,3
,4
]}

Domingo, Esteban ^{[2
,3
]}

机构：

[1] Univ Autonoma Barcelona, Vall dHebron Inst Recerca, Hosp Univ Vall dHebron, Liver Unit,Internal Med,Lab Malalties Hepat, Barcelona 08035, Spain

[2] CSIC UAM, Ctr Biol Mol Severo Ochoa, Madrid 28049, Spain

[3] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona 08035, Spain

[4] Univ Autonoma Barcelona, Bellaterra 08193, Spain

[5] Roche Diagnost SL, Sant Cugat Del Valles 08174, Spain

来源：

VIRUSES-BASEL | 2015年 / 7卷 / 11期

关键词：

viral quasi-species; hepatitis C virus; viral resistance; antiviral treatment; CELL-CULTURE SYSTEMS; INTERFERON-ALPHA-2B PLUS RIBAVIRIN; LONG-TERM PERSISTENCE; GENOTYPE; PEGINTERFERON ALPHA-2B; COMBINATION THERAPY; PROTEASE INHIBITORS; NS5A INHIBITOR; POLYMERASE INHIBITORS; VARIANTS RESISTANT;

D O I：

10.3390/v7112902

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Selection of inhibitor-resistant viral mutants is universal for viruses that display quasi-species dynamics, and hepatitis C virus (HCV) is no exception. Here we review recent results on drug resistance in HCV, with emphasis on resistance to the newly-developed, directly-acting antiviral agents, as they are increasingly employed in the clinic. We put the experimental observations in the context of quasi-species dynamics, in particular what the genetic and phenotypic barriers to resistance mean in terms of exploration of sequence space while HCV replicates in the liver of infected patients or in cell culture. Strategies to diminish the probability of viral breakthrough during treatment are briefly outlined.

引用

页码：5746 / 5766

页数：21

共 158 条

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