The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder

被引：25

作者：

Gan-Or, Ziv ^{[1
,2
,3
]}

Montplaisir, Jacques Y. ^{[4
,5
]}

Ross, Jay P. ^{[2
]}

Poirier, Judes ^{[6
,7
]}

Warby, Simon C. ^{[4
,5
]}

Arnulf, Isabelle ^{[8
,9
]}

Strong, Stephanie ^{[1
]}

Dauvilliers, Yves ^{[10
]}

Leblond, Claire S. ^{[1
,2
]}

Hu, Michele T. M. ^{[11
,12
]}

Hogl, Birgit ^{[13
]}

Stefani, Ambra ^{[13
]}

Monaca, Christelle Charley ^{[14
,15
]}

de Cock, Valerie Cochen ^{[16
,17
]}

Boivin, Michel ^{[18
,19
]}

Ferini-Strambi, Luigi ^{[20
]}

Plazzi, Giuseppe ^{[21
,22
]}

Antelmi, Elena ^{[21
]}

Young, Peter ^{[23
]}

Heidbreder, Anna ^{[23
]}

Barber, Thomas R. ^{[11
,12
]}

Evetts, Samuel G. ^{[11
,12
]}

Rolinski, Michal ^{[11
,12
]}

Dion, Patrick A. ^{[1
,3
]}

Desautels, Alex ^{[4
,24
]}

Gagnon, Jean-Francois ^{[4
,25
]}

Dupre, Nicolas ^{[26
]}

Postuma, Ronald B. ^{[3
,27
]}

Rouleau, Guy A. ^{[1
,2
,3
]}

机构：

[1] McGill Univ, Montreal Neurol Inst, 1033 Pine Ave West, Montreal, PQ H3A 1A1, Canada

[2] McGill Univ, Dept Human Genet, Montreal, PQ, Canada

[3] McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ, Canada

[4] Hop Sacre Coeur, Ctr Etud Avancees Med Sommeil, Montreal, PQ, Canada

[5] Univ Montreal, Dept Psychiat, Montreal, PQ, Canada

[6] McGill Univ, Dept Psychiat, Montreal, PQ, Canada

[7] Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada

[8] UPMC Paris 6 Univ, Pitie Salpetriere Hosp, Sleep Disorders Unit, Ctr Rech,Inst Cerveau & Moelle Epiniere, Paris, France

[9] UPMC Paris 6 Univ, Sorbonne Univ, Paris, France

[10] CHU Montpellier, Dept Neurol, Natl Reference Network Narcolepsy, Hop Gui de Chauliac,INSERM U1061,Sleep Unit, Montpellier, France

[11] Univ Oxford, OPDC, Oxford, England

[12] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England

[13] Med Univ Innsbruck, Dept Neurol, Sleep Disorders Clin, Innsbruck, Austria

[14] Univ Lille North France, CHU Lille, Dept Clin Neurophysiol, Lille, France

[15] Univ Lille North France, Sleep Ctr, CHU Lille, Lille, France

[16] Beau Soleil Clin, Sleep & Neurol Unit, Montpellier, France

[17] Univ Montpellier, EuroMov, Montpellier, France

[18] Univ Laval, GRIP, Ecole Psychol, Quebec City, PQ, Canada

[19] Tomsk State Univ, Inst Genet Neurobiol & Social Fdn Child Dev, Tomsk, Russia

[20] Univ Vita Salute San Raffaele, Dept Neurol Sci, Milan, Italy

[21] Univ Bologna, Alma Mater Studiorum, Dept Biomed & Neuromotor Sci DIBINEM, Bologna, Italy

[22] IRCCS, Inst Neurol Sci Bologna, Bologna, Italy

[23] Univ Munster, Dept Sleep Med & Neuromuscular Disorders, Munster, Germany

[24] Univ Montreal, Dept Neurosci, Montreal, PQ, Canada

[25] Univ Quebec, Dept Psychol, Montreal, PQ, Canada

[26] Univ Laval, Fac Med, CHU Quebec Enfant Jesus, Quebec City, PQ, Canada

[27] Montreal Gen Hosp, Dept Neurol, Montreal, PQ, Canada

来源：

NEUROBIOLOGY OF AGING | 2017年 / 49卷

关键词：

APOE; REM sleep behavior disorder; Genetics; Parkinson's disease; Dementia with Lewy bodies; MUTATIONS; DISEASE;

D O I：

10.1016/j.neurobiolaging.2016.10.002

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The present study aimed to examine whether the APOE epsilon 4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE epsilon 4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88-1.40, p = 0.41). APOE epsilon 4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy ( 0.14, p = 1.0). The APOE epsilon 4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：218.e13 / 218.e15

页数：3

共 5 条

[1] ABSENCE OF LRRK2 MUTATIONS IN A COHORT OF PATIENTS WITH IDIOPATHIC REM SLEEP BEHAVIOR DISORDER [J].

Fernandez-Santiago, Ruben ;

Iranzo, Alex ;

Gaig, Carles ;

Serradell, Monica ;

Fernandez, Manel ;

Tolosa, Eduardo ;

Santamaria, Joan ;

Ezquerra, Mario .

NEUROLOGY, 2016, 86 (11) :1072-1073

[2] Parkinson's Disease Genetic Loci in Rapid Eye Movement Sleep Behavior Disorder [J].

Gan-Or, Z. ;

Girard, S. L. ;

Noreau, A. ;

Leblond, C. S. ;

Gagnon, J. F. ;

Arnulf, I. ;

Mirarchi, C. ;

Dauvilliers, Y. ;

Desautels, A. ;

Mitterling, T. ;

De Cock, V. Cochen ;

Frauscher, B. ;

Monaca, C. ;

Hogl, B. ;

Dion, P. A. ;

Postuma, R. B. ;

Montplaisir, J. Y. ;

Rouleau, G. A. .

JOURNAL OF MOLECULAR NEUROSCIENCE, 2015, 56 (03) :617-622

[3] GBA mutations are associated with Rapid Eye Movement Sleep Behavior Disorder [J].

Gan-Or, Ziv ;

Mirelman, Anat ;

Postuma, Ronald B. ;

Arnulf, Isabelle ;

Bar-Shira, Anat ;

Dauvilliers, Yves ;

Desautels, Alex ;

Gagnon, Jean-Francois ;

Leblond, Claire S. ;

Frauscher, Birgit ;

Alcalay, Roy N. ;

Saunders-Pullman, Rachel ;

Bressman, Susan B. ;

Marder, Karen ;

Monaca, Christelle ;

Hoegl, Birgit ;

Orr-Urtreger, Avi ;

Dion, Patrick A. ;

Montplaisir, Jacques Y. ;

Giladi, Nir ;

Rouleau, Guy A. .

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 2015, 2 (09) :941-945

[4] Neurodegenerative Disorder Risk in Idiopathic REM Sleep Behavior Disorder: Study in 174 Patients [J].

Iranzo, Alex ;

Fernandez-Arcos, Ana ;

Tolosa, Eduard ;

Serradell, Monica ;

Luis Molinuevo, Jose ;

Valldeoriola, Francesc ;

Gelpi, Ellen ;

Vilaseca, Isabel ;

Sanchez-Valle, Raquel ;

Llado, Albert ;

Gaig, Carles ;

Santamaria, Joan .

PLOS ONE, 2014, 9 (02)

[5] APOLIPOPROTEIN E4 AND ALZHEIMERS-DISEASE PATHOLOGY IN LEWY BODY DISEASE AND IN OTHER BETA-AMYLOID-FORMING DISEASES [J].

PICKERINGBROWN, SM ;

MANN, DMA ;

BOURKE, JP ;

ROBERTS, DA ;

BALDERSON, D ;

BURNS, A ;

BYRNE, J ;

OWEN, F .

LANCET, 1994, 343 (8906) :1155-1155

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