Whole-Genome Sequencing of Measles Virus Genotypes H1 and D8 During Outbreaks of Infection Following the 2010 Olympic Winter Games Reveals Viral Transmission Routes

被引：47

作者：

Gardy, Jennifer L. ^{[1
,2
]}

Naus, Monika ^{[1
,2
]}

Amlani, Ashraf ^{[1
]}

Chung, Walter ^{[4
]}

Kim, Hochan ^{[11
]}

Tan, Malcolm ^{[3
,12
]}

Severini, Alberto ^{[9
]}

Krajden, Mel

Puddicombe, David ^{[1
]}

Sahni, Vanita ^{[1
,10
]}

Hayden, Althea S. ^{[5
,7
]}

Gustafson, Reka ^{[7
]}

Henry, Bonnie ^{[1
,2
,8
]}

Tang, Patrick ^{[6
]}

机构：

[1] Univ British Columbia, British Columbia Ctr Dis Control, Vancouver, BC V5Z 1M9, Canada

[2] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC V5Z 1M9, Canada

[3] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 1M9, Canada

[4] Univ British Columbia, Dept Occupat Sci & Occupat Therapy, Vancouver, BC V5Z 1M9, Canada

[5] Univ British Columbia, Dept Family Practice, Vancouver, BC V5Z 1M9, Canada

[6] British Columbia Minist Hlth, British Columbia Publ Hlth Microbiol & Reference, Victoria, BC, Canada

[7] British Columbia Minist Hlth, Vancouver Coastal Hlth Author, Victoria, BC, Canada

[8] British Columbia Minist Hlth, Office Prov Hlth Officer, Victoria, BC, Canada

[9] Publ Hlth Agcy Canada, Natl Microbiol Lab, Winnipeg, MB, Canada

[10] Alberta Hlth & Wellness, Edmonton, AB, Canada

[11] Thomas Jefferson Univ, Emergency Med, Philadelphia, PA 19107 USA

[12] Saba Univ, Sch Med, Municipal Netherlands, Tabriz, Iran

来源：

JOURNAL OF INFECTIOUS DISEASES | 2015年 / 212卷 / 10期

关键词：

measles; genomics; epidemiology; transmission; outbreak; mass gathering; ELIMINATION; EVOLUTIONARY;

D O I：

10.1093/infdis/jiv271

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We used whole-genome sequencing to investigate a dual-genotype outbreak of measles occurring after the XXI Olympic Winter Games in Vancouver, Canada. By sequencing 27 complete genomes from H1 and D8 genotype measles viruses isolated from outbreak cases, we estimated the virus mutation rate, determined that person-to-person transmission is typically associated with 0 mutations between isolates, and established that a single introduction of H1 virus led to the expansion of the outbreak beyond Vancouver. This is the largest measles genomics project to date, revealing novel aspects of measles virus genetics and providing new insights into transmission of this reemerging viral pathogen.

引用

页码：1574 / 1578

页数：5

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