New polyhydroxylated pregnadienes from the South African soft coral Pieterfaurea unilobata

被引：13
作者：
Beukes, DR
DaviesColeman, MT
Eggleston, DS
Haltiwanger, RC
Tomkowicz, B
机构：
[1] RHODES UNIV,DEPT CHEM,ZA-6140 GRAHAMSTOWN,SOUTH AFRICA
[2] SMITHKLINE BEECHAM PHARMACEUT,DEPT PHYS & STRUCT CHEM,KING OF PRUSSIA,PA 19406
来源：
JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 06期
关键词：
D O I：
10.1021/np960684h
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Seven pregnadiene metabolites, pregna-5,20-diene-3 alpha,7 alpha-diol 3 alpha-acetate (1), pregna-5,20-diene-3 beta,7 alpha-diol 7 alpha-acetate (2), pregna-5,20-dien-3 beta-ol (3), pregna-5,20-diene-3 alpha, 7 alpha,11 alpha-triol 3 alpha-acetate (4), pregna-5,20-diene-3 alpha,7 alpha,11 alpha-triol 3 alpha,7 alpha-diacetate (5), pregna-5,20-diene-3 alpha,7 alpha, 19-triol 3 alpha,19-diacetate (6), and pregna-5,20-diene-3 alpha,7 alpha,11 alpha,19-tetrol 3 alpha,7 alpha,19-triacetate (7) were isolated from an EtOAc extract of the endemic South African soft coral Pieterfaurea unilobata. Standard spectroscopic techniques including X-ray crystallography were used to determine the structures of these compounds, which, apart from compound 3, are all new Delta(5),Delta(20) pregnadiene steroids.
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页码：573 / 577
页数：5
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