Plasmonic liposomes for synergistic photodynamic and photothermal therapy

被引：23
作者：
Oh, Jeongmin [1 ,2 ]
Yoon, Hwan-Jun [1 ,2 ]
Park, Ji-Ho [1 ,2 ,3 ]
机构：
[1] Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Taejon 305701, South Korea
[2] Korea Adv Inst Sci & Technol, Inst Opt Sci & Technol, Taejon 305701, South Korea
[3] Korea Adv Inst Sci & Technol, Inst Nanocentury, Taejon 305701, South Korea
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2014年 / 2卷 / 17期
关键词：
ZINC(II) PHTHALOCYANINE; ALUMINUM PHTHALOCYANINE; GOLD NANOPARTICLES; CANCER-THERAPY; PHOTOSENSITIZER; NANOSHELLS; EFFICIENCY; TUMORS; PORPHYRINS; NANOCAGES;
D O I：
10.1039/c3tb21452d
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
In the present study, plasmonic liposomes (PLs) loaded with photosensitizers were developed for synergistic photodynamic and photothermal therapy. These PLs were prepared by incorporating a photosensitizer, ZnPc, into the liposomal membrane for photodynamic therapy (PDT) and coating a gold nanofilm onto the surface for photothermal therapy (PTT). The gold coating was optimized to efficiently absorb the wavelength of light at which ZnPc is activated for PDT. The photosensitizing effect of ZnPc was synergistically enhanced upon single light irradiation due to local photothermal heating and the surface plasmon resonance of the gold nanostructure. Furthermore, combined photodynamic and photothermal therapy using ZnPc-PLs exhibited a remarkably enhanced therapeutic efficacy on cancer cells in vitro compared to PDT or PTT alone. Therefore, we believe that this dual photoactive nanodevice with a synergistic therapeutic index has great potential to improve the current phototherapy of cancer.
引用
收藏
页码：2592 / 2597
页数：6
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