Acquired hemophilia A: an underdiagnosed, severe bleeding disorder

被引：17

作者：

Zdziarska, Joanna ^{[1
]}

Musial, Jacek ^{[2
]}

机构：

[1] Jagiellonian Univ, Coll Med, Dept Hematol, PL-31501 Krakow, Poland

[2] Jagiellonian Univ, Coll Med, Dept Med 2, PL-31501 Krakow, Poland

来源：

POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ-POLISH ARCHIVES OF INTERNAL MEDICINE | 2014年 / 124卷 / 04期

关键词：

acquired hemophilia; activated prothrombin bleeding disorder; complex concentrate; recombinant activated factor VII; TRANSPLACENTAL TRANSFER; MANAGEMENT; INHIBITORS; DIAGNOSIS; SURVEILLANCE;

D O I：

10.20452/pamw.2192

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acquired hemophilia is a rare bleeding disorder caused by autoantibodies that inhibit coagulation factor VIII. In most cases, it manifests with severe, often life--threatening bleeds. Acquired hemophilia may be idiopathic or secondary to another condition, most commonly other autoimmune disease or cancer. Treatment is directed to stop bleeding and eradicate inhibitory autoantibodies. Like in most life--threatening conditions, early diagnosis and treatment are essential for good prognosis. Prompt diagnosis and treatment of acquired hemophilia are constantly improving owing to the increasing availability of laboratory diagnostic tests and growing awareness of physicians of various specialties.

引用

页码：200 / 206

页数：7

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