Genotypic analysis of Mycobacterium tuberculosis isolates from a Lisbon hospital in Portugal

被引：0
作者：
Perdigao, Joao [3 ]
Milho, Catarina [3 ]
Carrilho, Lurdes [4 ,5 ]
Brum, Laura [2 ,6 ,7 ,8 ]
Portugal, Isabel [1 ,2 ]
机构：
[1] Univ Lisbon, Ctr Patogenese Mol, URIA, Fac Farm,Inst Nacl Saude Dr Ricardo Jorge, P-1649003 Lisbon, Portugal
[2] Inst Nacl Saude Dr Ricardo Jorge, Dept Doencas Infecciosas, Lisbon, Portugal
[3] Univ Lisbon, Mol Pathogenesis Ctr, URIA, Sch Pharm, P-1649003 Lisbon, Portugal
[4] Hosp Pulido Valente, Seccao Micobacterias, Serv Pathol Clin, Lisbon, Portugal
[5] Hosp Pulido Valente, Mycobacteria Sect, Clin Pathol Unit, Lisbon, Portugal
[6] Univ Nova Lisboa, Fac Ciencias Med, P-1200 Lisbon, Portugal
[7] Univ Nova Lisboa, Sch Med Sci, P-1200 Lisbon, Portugal
[8] Inst Nacl Saude Dr Ricardo Jorge, Dept Infect Dis, Lisbon, Portugal
来源：
REVISTA PORTUGUESA DE PNEUMOLOGIA | 2009年 / 15卷 / 05期
关键词：
Lisboa family; tuberculosis; multidrug resistance; MIRU; MULTIDRUG-RESISTANT TUBERCULOSIS; FRAGMENT-LENGTH-POLYMORPHISM; MOLECULAR EPIDEMIOLOGY; GENOMIC DELETIONS; STRAINS; TRANSMISSION; LINEAGE; MUTATIONS; INSIGHTS; COMPLEX;
D O I：
暂无
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Portugal has one of the highest tuberculosis notification rates of the European Union with Lisbon Health Region having an incidence rate well above the national average. The present study analyses the transmission, drug susceptibility and characteristics of a study population from a Central Lisbon's Hospital. One hundred and thirty-two Mycobacterium tuberculosis clinical isolates were previously tested for drug susceptibility to first-line drugs. The multidrug (MDR) resistance rate was found to be 3.0%, while 13.6% of the isolates were resistant to one or more first-line drugs. HIV serology was available for 98 patients, 26 (26.5%) were positive. Genotyping was performed by MIRU-VNTR and 53 (40,2%) out of the 132 isolates were found to be distributed through 17 MIRU-VNTR clusters of two or more isolates. Lisboa strains accounted for 25.8% of all strains. We conclude that transmission of resistant and susceptible Mycobacterium tuberculosis strains is occurring, with special concern for Lisboa strains.
引用
收藏
页码：761 / 769
页数：9
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