Preliminary clinical trials of serum free cell culture medium as a treatment for chronic atrophic ulcers

被引：4

作者：

Lindenbaum, E

HarShai, Y

Ullmann, Y

Feitelberg, AL

Tendler, M

Beach, D

Berger, J

Dvir, E

Hirshowitz, B

机构：

[1] Technion,Morphology Research Unit, Faculty of Medicine

[2] Rambam Medical Center,Plastic Surgery Department

[3] Surgery and Dermatology Clinic,General Sick Fund

[4] Plastic Surgery Clinic,General Sick Fund

[5] Plastic Surgery Clinic,Maccabi Sick Fund

[6] Technion-Israel Institute of Technology,Morphology Research Unit, Faculty of Medicine

来源：

EUROPEAN JOURNAL OF PLASTIC SURGERY | 1997年 / 20卷 / 03期

关键词：

leg ulcers; culture medium; anabolic hormones;

D O I：

10.1007/BF01002042

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Among the common treatments for chronic atrophic wounds, moist dressings are used to create optimal environment and prevent desiccation of the wound bed. Modified serum free cell culture medium supplemented with nonsteroidal anabolic hormones thyroxine, growth hormone, insulin and transferrin was gelled in 1% Agarose. The gel was applied to the surface of chronic atrophic wounds (1 ml/cm(2)) once a day. All the wounds included in this study were clear of infection following treatment with topical antiseptics and antibiotics. The study was performed on 92 patients suffering from chronic leg ulcers. Etiologies of the ulcers varied from venous insufficiency, arterial insufficiency, insulin-dependent and non-dependent diabetic ulcers or combinations of the above. Complete wound closure was obtained in 50 patients. In the remaining 42 patients, the treatment was discontinued because of unrelated medical or psychiatric problems - 13 patients, noncompliance - 16 patients, relocation - 12 patients, and infection - 1 patient.

引用

页码：115 / 120

页数：6