Biological functions of m6A methyltransferases

被引：42
作者：
Gu, Jianzhong [1 ,2 ]
Zhan, Yu [2 ]
Zhuo, Lvjia [1 ,3 ]
Zhang, Qin [1 ,3 ]
Li, Guohua [1 ,3 ]
Li, Qiujie [1 ,3 ]
Qi, Shasha [1 ,3 ]
Zhu, Jinyu [1 ,3 ]
Lv, Qun [4 ]
Shen, Yingying [2 ]
Guo, Yong [2 ]
Liu, Shuiping [1 ,3 ]
Xie, Tian [1 ,3 ]
Sui, Xinbing [1 ,3 ]
机构：
[1] Hangzhou Normal Univ, Sch Med, Coll Pharm, Hangzhou 311121, Zhejiang, Peoples R China
[2] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Oncol, 54 Youdian Rd, Hangzhou 310006, Zhejiang, Peoples R China
[3] Hangzhou Normal Univ, Collaborat Innovat Ctr Tradit Chinese Med Zhejian, Engn Lab Dev & Applicat Tradit Chinese Med, Key Lab Elemene Class Anticanc Chinese Med, Hangzhou 311121, Zhejiang, Peoples R China
[4] Hangzhou Normal Univ, Affiliated Hosp, Sch Med, Dept Resp Med, Hangzhou 310015, Zhejiang, Peoples R China
来源：
CELL AND BIOSCIENCE | 2021年 / 11卷 / 01期
基金：
中国国家自然科学基金;
关键词：
M(6)A methyltransferase; Growth and development; Metabolism; Infection and immunity; Tumour progression;
D O I：
10.1186/s13578-020-00513-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
M(6)A methyltransferases, acting as a writer in N6-methyladenosine, have attracted wide attention due to their dynamic regulation of life processes. In this review, we first briefly introduce the individual components of m(6)A methyltransferases and explain their close connections to each other. Then, we concentrate on the extensive biological functions of m(6)A methyltransferases, which include cell growth, nerve development, osteogenic differentiation, metabolism, cardiovascular system homeostasis, infection and immunity, and tumour progression. We summarize the currently unresolved problems in this research field and propose expectations for m(6)A methyltransferases as novel targets for preventive and curative strategies for disease treatment in the future.
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页数：16
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