Effect of interferon α2a in cystoid macular edema due to intraocular infection

被引：16

作者：

Qian, Zhuyun ^{[1
,2
]}

Fardeau, Christine ^{[1
]}

Cardoso, Joao Nobre ^{[1
,3
]}

Jellab, Badr ^{[1
]}

Fan, Xianqun ^{[2
]}

Phuc LeHoang ^{[1
]}

机构：

[1] Univ Paris 06, Dept Ophthalmol, Pitie Salpetriere Hosp, Vis & Handicap DHU,Reference Ctr Rare Dis, F-75013 Paris, France

[2] Shanghai Jiao Tong Univ, Dept Ophthalmol, Sch Med, Shanghai Peoples Hosp 9, Shanghai 200030, Peoples R China

[3] Hosp Garcia de Orta, Dept Ophthalmol, Almada, Portugal

来源：

EUROPEAN JOURNAL OF OPHTHALMOLOGY | 2015年 / 25卷 / 05期

关键词：

Cystoid macular edema; Interferon alpha 2a; Intraocular infection; BEHCETS-DISEASE; UVEITIS; POSTERIOR; EFFICACY; PANUVEITIS;

D O I：

10.5301/ejo.5000591

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: Cystoid macular edema (CME) is a severe complication and a major cause of visual loss in patients with intraocular infection. In this type of CME, therapeutic strategies remain controversial. We aimed to investigate the efficacy and tolerability of interferon (IFN)-alpha 2a in cystoid macular edema caused by intraocular infection. Methods: In this retrospective, noncomparative, interventional case series, 5 patients (6 eyes) who were diagnosed with intraocular infection with chronic CME were included. Interferon-alpha 2a (3 million units 3 times a week) was administered subcutaneously. Clinical observations were recorded before and after treatment. Results: The average duration of CME before treatment with IFN-alpha was 26 months. According to the preset criteria, IFN-alpha 2a therapy was shown to be effective in 2 patients (3 eyes), effective dose-dependent in 2 patients, and partly effective in 1 patient, and was well-tolerated in 4 patients. The most common side effect was flu-like symptoms. Conclusions: Interferon alpha-2a may be an effective alternative treatment for CME due to intraocular infection that is resistant to other treatment. Studies with larger sample sizes are required to confirm this conclusion.

引用

页码：431 / 436

页数：6

共 25 条

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