A correspondence between the models of Hodgkin-Huxley and FitzHugh-Nagumo revisited

被引:11
作者
Postnikov, Eugene B. [1 ]
Titkova, Olga V. [2 ]
机构
[1] Kursk State Univ, Dept Theoret Phys, Radishcheva St 33, Kursk 305000, Russia
[2] Kursk State Univ, Dept Math Anal & Appl Math, Radishcheva St 33, Kursk 305000, Russia
来源
EUROPEAN PHYSICAL JOURNAL PLUS | 2016年 / 131卷 / 11期
基金
俄罗斯科学基金会;
关键词
EXCITABILITY; DYNAMICS;
D O I
10.1140/epjp/i2016-16411-1
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
We present the discussion on the possibility to scale the classical dimensionless FitzHugh-Nagumo model of neuronal self-sustained oscillations to the range of variables corresponding to the results, which are provided by the biophysically relevant reduced two-dimensional Hodgkin-Huxley equations (the Rinzel model). It is shown that there exists a relatively simple choice of affine transformation, which results in time-dependent solutions, which reproduce with a high accuracy the time course of the recovery variable and the sharp onsets (intervals of fast motions on a phase trajectories) of the voltage spikes. As for the latter, the reasons for unavoidable difference are discussed as well as a necessity of taking into account applied current values during such a scaling procedure.
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页数:9
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