Dual Photoredox/Nickel-Catalyzed Three-Component Carbofunctionalization of Alkenes

被引：152

作者：

Garcia-Dominguez, Andres ^{[1
]}

Mondal, Rahul ^{[1
]}

Nevado, Cristina ^{[1
]}

机构：

[1] Univ Zurich, Dept Chem, Winterthurerstr 190, CH-8057 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 35期

基金：

瑞士国家科学基金会; 欧洲研究理事会;

关键词：

alkenes; multicomponent reactions; nickel; photochemistry; reaction mechanisms; CROSS-COUPLING REACTIONS; CARBONYL ALKYL BROMIDES; INTERMOLECULAR TRIFLUOROMETHYLARYLATION; SULFONATED OXINDOLES; RADICAL GENERATION; NICKEL CATALYSIS; SULFINATE SALTS; ARYL BROMIDES; ONE-POT; LIGHT;

D O I：

10.1002/anie.201906692

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The potential of merging photoredox and nickel catalysis to perform multicomponent alkene difunctionalizations under visible-light irradiation is demonstrated here. Secondary and tertiary alkyl groups, as well as sulfonyl moieties can be added to the terminal position of the double bond with simultaneous arylation of the internal carbon atom in a single step under mild reaction conditions. The process, devoid of stoichiometric additives, benefits from the use of bench-stable and easy-to-handle reagents, is operationally simple, and tolerates a wide variety of functional groups.

引用

页码：12286 / 12290

页数：5

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