Eosinophil Peroxidase Staining Enhances the Diagnostic Utility of the Cytosponge in Eosinophilic Esophagitis

被引：5

作者：

Masuda, Mia Y. ^{[1
,2
,3
]}

Barshow, Suzanne M. ^{[4
]}

Garg, Shipra ^{[5
]}

Putikova, Arina ^{[1
]}

LeSuer, William E. ^{[1
]}

Alexander, Jeffrey A. ^{[6
]}

Katzka, David A. ^{[6
]}

Dellon, Evan S. ^{[7
]}

Kita, Hirohito ^{[1
,2
,3
]}

Horsley-Silva, Jennifer L. ^{[8
]}

Doyle, Alfred D. ^{[1
]}

Wright, Benjamin L. ^{[1
,4
]}

机构：

[1] Mayo Clin Arizona, Dept Med, Div Allergy Asthma & Clin Immunol, Scottsdale, AZ 85259 USA

[2] Mayo Clin, Dept Immunol, Rochester, MN USA

[3] Mayo Clin Arizona, Scottsdale, AZ USA

[4] Phoenix Childrens Hosp, Div Pulmonol, Sect Allergy & Immunol, Phoenix, AZ 85016 USA

[5] Phoenix Childrens Hosp, Div Lab Med & Pathol, Phoenix, AZ USA

[6] Dept Med, Div Gastroenterol & Hepatol, Rochester, MN USA

[7] Univ N Carolina, Div Gastroenterol & Hepatol, Sch Med, Chapel Hill, NC USA

[8] Mayo Clin, Dept Med, Div Gastroenterol & Hepatol, Scottsdale, AZ USA

来源：

CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY | 2022年 / 13卷 / 11期

关键词：

ACCURACY; SAFETY;

D O I：

10.14309/ctg.0000000000000534

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

INTRODUCTION:We aimed to assess the diagnostic utility of eosinophil peroxidase (EPX) staining on Cytosponge (CS) samples in eosinophilic esophagitis (EoE).METHODS:Esophageal biopsy (BX) samples from adult subjects with EoE were assessed using peak eosinophils per high-power field (eos/hpf), EPX, and the EoE histologic scoring system. EPX staining and eos/hpf were compared (BX vs CS).RESULTS:CS EPX positivity correlated with eos/hpf (CS [r = 0.82, P < 0.0001]; BX [r = 0.65, P < 0.0001]) and EoE histologic scoring system (grade [r = 0.62, P < 0.00001]; stage [r = 0.61, P < 0.0001]). CS EPX identified subjects with active EoE (area under the curve = 0.86, P < 0.0001).DISCUSSION:The correlation of CS EPX with eosinophilic inflammation and histologic disease severity supports its diagnostic utility in EoE.

引用

页数：4

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