Integrative miRNA and whole-genome analyses of epicardial adipose tissue in patients with coronary atherosclerosis

被引：89

作者：

Vacca, Michele ^{[1
,2
,3
,7
]}

Di Eusanio, Marco ^{[4
,8
]}

Cariello, Marica ^{[1
,5
]}

Graziano, Giusi ^{[1
,5
]}

D'Amore, Simona ^{[1
,2
,5
]}

Petridis, Francesco Dimitri ^{[4
]}

D'orazio, Andria ^{[2
]}

Salvatore, Lorena ^{[2
]}

Tamburro, Antonio ^{[2
]}

Folesani, Gianluca ^{[4
]}

Rutigliano, David ^{[6
]}

Pellegrini, Fabio ^{[2
]}

Sabba, Carlo ^{[1
]}

Palasciano, Giuseppe ^{[1
]}

Di Bartolomeo, Roberto ^{[4
]}

Moschetta, Antonio ^{[1
,2
,5
]}

机构：

[1] Univ Bari Aldo Moro, Dept Interdisciplinary Med, Piazza Giulio Cesare 11, I-70124 Bari, Italy

[2] Fdn Mario Negri Sud, Santa Maria Imbaro, CH, Italy

[3] G Annunzio Univ Fdn, Ageing Res Ctr CeSI, Chieti, Italy

[4] Univ Bologna, S Orsola Malpighi Hosp, Cardiovasc Dept, Bologna, Italy

[5] Natl Canc Res Ctr IRCCS Giovanni Paolo II, Bari, Italy

[6] San Paolo Hosp, Unit Cardiol, Bari, Italy

[7] Univ Cambridge, MRC HNR, Cambridge, England

[8] Giuseppe Mazzini Hosp, Cardiovasc Dept, Cardiac Surg Unit, Bologna, Italy

来源：

CARDIOVASCULAR RESEARCH | 2016年 / 109卷 / 02期

基金：

英国医学研究理事会;

关键词：

Epicardial adipose tissue; Gene expression; miRNA; Metabolic syndrome; Nuclear receptors; ARTERY-DISEASE; IN-VIVO; EXPRESSION; MICRORNAS; RECEPTOR; INFLAMMATION; FAT; ATRIAL; MECHANISMS; GAMMA;

D O I：

10.1093/cvr/cvv266

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Epicardial adipose tissue (EAT) is an atypical fat depot surrounding the heart with a putative role in the development of atherosclerosis. Methods and results We profiled genes and miRNAs in perivascular EAT and subcutaneous adipose tissue (SAT) of metabolically healthy patients without coronary artery disease (CAD) vs. metabolic patients with CAD. Compared with SAT, a specific tuning of miRNAs and genes points to EAT as a tissue characterized by a metabolically active and pro-inflammatory profile. Then, we depicted both miRNA and gene signatures of EAT in CAD, featuring a down-regulation of genes involved in lipid metabolism, mitochondrial function, nuclear receptor transcriptional activity, and an up-regulation of those involved in antigen presentation, chemokine signalling, and inflammation. Finally, we identified miR-103-3p as candidate modulator of CCL13 in EAT, and a potential biomarker role for the chemokine CCL13 in CAD. Conclusion EAT in CADis characterized by changes in the regulation of metabolism and inflammation with miR-103-3p/CCL13 pair as novel putative actors in EAT function and CAD.

引用

页码：228 / 239

页数：12

共 60 条

[51] Coronary perivascular adipose tissue characteristics are related to atherosclerotic plaque size and composition. A post-mortem study [J].