Nanocapsules of Sterculia striata acetylated polysaccharide as a potential monomeric amphotericin B delivery matrix

被引：25

作者：

Sombra, Fernanda Matoso ^{[1
]}

Richter, Ana Rosa ^{[1
]}

de Araujo, Alyne Rodrigues ^{[2
]}

Silva Ribeiro, Fabio de Oliveira ^{[2
]}

Souza Mendes, Josilayne de Fatima ^{[3
]}

dos Santos Fontenelle, Raquel Oliveira ^{[3
]}

da Silva, Durcilene Alves ^{[2
]}

Beserra de Paula, Haroldo Cesar ^{[1
]}

de Andrade Feitosa, Judith Pessoa ^{[1
]}

Goycoolea, Francisco Martin ^{[4
,5
]}

Monteiro de Paula, Regina Celia ^{[1
]}

机构：

[1] UFG, Dept Organ & Inorgan Chem, Caixa Postal 6021,Humberto Monte S-N,Campus Pici, BR-60455760 Fortaleza, Ceara, Brazil

[2] Univ Fed Piaui, BIOTEC, Nucleo Pesquisa Biodiversidade & Biotecnol, Campus Minist Reis Velloso, Teresina, Brazil

[3] Univ Estadual Vale Acarau, Ctr Ciencias Agr & Biol, Curso Ciencias Biol, Sobral, Brazil

[4] Univ Munster, Inst Plant Biol & Biotechnol, Schlossgarten 3, D-48149 Munster, Germany

[5] Univ Leeds, Sch Food Sci & Nutr, Leeds LS16 7PA, W Yorkshire, England

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2019年 / 130卷

关键词：

Acetylated derivatives; Sterculia striata; Nanocapsules; Amphotericin B; DRUG CARRIERS; NANOPARTICLES; TOXICITY; AGGREGATION; FORMULATION; RELEASE; ANTIOXIDANT; DERIVATIVES; MICELLES; BEHAVIOR;

D O I：

10.1016/j.ijbiomac.2019.02.076

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stable oil nanocapsules based on acetylated Sterculia striata polysaccharide (ASSP) were produced without the use of a surfactant, and derivatives of ASSP with four different degrees of substitution (DS) were synthesised. The data revealed that only derivatives with high DS were able to produce nanocapsules (NC), which exhibited monomodal size distribution profiles with a Z-average particle size, lambda-potential, and polydispersity index (PDI) that were dependent on ASSP DS and concentration. Nanocapsules were loaded with amphotericin B (AMB) with encapsulation efficiencies (EE%) that were dependent on drug and ASSP concentrations and DS. A maximum EE% value of 99.2% was achieved, and the loaded AMB was found to be in a monomeric form, even with a concentration one hundredfold higher than that usually observed for commercial AMB aqueous solutions. Loaded nanocapsules show an in vitro controlled release of AMB. As the monomeric AMB state decreased drug toxicity, ASSP nanocapsules loaded with AMB (NC1.68) have potential for use as a drug delivery system. AMB loaded NC 1.68 keeps its activity against 5 strains of Candida albicans tested. (C) 2019 Published by Elsevier B.V.

引用

页码：655 / 663

页数：9

共 53 条

[1] Amphotericin B encapsulated in micelles based on poly(ethylene oxide)-block-poly(L-amino acid) derivatives exerts reduced in vitro hemolysis but maintains potent in vivo antifungal activity [J].