Viscous optical clearing agent for in vivo optical imaging

被引：15

作者：

Deng, Zijian ^{[1
]}

Jing, Lijia ^{[2
]}

Wu, Ning ^{[1
]}

Lv, Pengyu ^{[3
]}

Jiang, Xiaoyun ^{[1
]}

Ren, Qiushi ^{[1
]}

Li, Changhui ^{[1
]}

机构：

[1] Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China

[2] Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150001, Peoples R China

[3] Peking Univ, Coll Engn, Dept Mech & Engn Sci, Beijing 100871, Peoples R China

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2014年 / 19卷 / 07期

基金：

中国国家自然科学基金;

关键词：

optical clearing; photoacoustic microscopy; optical coherent tomography; optical imaging; ultrasonic coupling; PHOTOACOUSTIC MICROSCOPY; DEPTH ENHANCEMENT; RESOLUTION; CONTRAST;

D O I：

10.1117/1.JBO.19.7.076019

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

By allowing more photons to reach deeper tissue, the optical clearing agent (OCA) has gained increasing attention in various optical imaging modalities. However, commonly used OCAs have high fluidity, limiting their applications in in vivo studies with oblique, uneven, or moving surfaces. In this work, we reported an OCA with high viscosity. We measured the properties of this viscous OCA, and tested its successful performances in the imaging of a living animal's skin with two optical imaging modalities: photoacoustic microscopy and optical coherence tomography. Our results demonstrated that the viscous OCA has a great potential in the study of different turbid tissues using various optical imaging modalities. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)

引用

页数：6

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