Is radiation dose reduction the right answer for HPV-positive head and neck cancer?

被引：30

作者：

Kimple, Randall J. ^{[1
]}

Harari, Paul M. ^{[1
]}

机构：

[1] Univ Wisconsin, Sch Med & Publ Hlth, Carbone Canc Ctr, Dept Human Oncol, Madison, WI USA

来源：

ORAL ONCOLOGY | 2014年 / 50卷 / 06期

关键词：

Head and neck cancer; Human papillomavirus; Radiation; Dose reduction; SQUAMOUS-CELL CARCINOMA; HUMAN-PAPILLOMAVIRUS; OROPHARYNGEAL CANCER; PROGNOSTIC-SIGNIFICANCE; MOLECULAR MARKERS; IMPROVED SURVIVAL; UNITED-STATES; RADIOTHERAPY; TRIAL; ASSOCIATION;

D O I：

10.1016/j.oraloncology.2013.09.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients with head and neck squamous cell carcinoma (HNC) related to human papillomavirus (HPV) represent a growing and distinct patient cohort with unique molecular and epidemiologic characteristics. These patients have markedly improved survival outcomes compared to those with traditional HNC, leading some to advocate for treatment dose reduction. In this article, we review ongoing clinical trials investigating several ways to reduce therapeutic intensity for patients with HPV-positive HNC, discuss the risks and benefits associated with these trials, and summarize the data underlying the advancement of dose reduction trials for patients with HPV-positive HNC. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：560 / 564

页数：5

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