Enantioselective Total Synthesis of Natural Isoflavans: Asymmetric Transfer Hydrogenation/Deoxygenation of Isoflavanones with Dynamic Kinetic Resolution

被引：20
作者：
Kessberg, Anton [1 ]
Lueken, Tilo [1 ]
Metz, Peter [1 ]
机构：
[1] Tech Univ Dresden, Organ Chem 1, Fak Chem & Lebensmittelchem, Bergstr 66, D-01069 Dresden, Germany
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 10期
关键词：
ABNORMAL CLAISEN REARRANGEMENT; TRANSFER HYDROGENATION; SIGMATROPIC REARRANGEMENT; INHIBITORY-ACTIVITY; ERYTHRINA-ZEYHERI; NAEGLERIA-FOWLERI; DRUG TARGETS; PHENYL ETHER; FLAVONOIDS; CANCER;
D O I：
10.1021/acs.orglett.8b01034
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A concise and highly enantioselective synthesis of structurally diverse isoflavans from a single chromone is described. The key transformation is a single-step conversion of racemic isoflavanones into virtually enantiopure isoflavans by domino asymmetric transfer hydrogenation/deoxygenation with dynamic kinetic resolution.
引用
收藏
页码：3006 / 3009
页数：4
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