Tristetraprolin Mediates Anti-Inflammatory Effects of Carbon Monoxide on Lipopolysaccharide-Induced Acute Lung Injury

被引：24

作者：

Joe, Yeonsoo ^{[1
]}

Kim, Seul-Ki ^{[1
]}

Chen, Yingqing ^{[1
]}

Yang, Jung Wook ^{[2
]}

Lee, Jeong-Hee ^{[2
]}

Cho, Gyeong Jae ^{[3
,4
]}

Park, Jeong Woo ^{[1
]}

Chung, Hun Taeg ^{[1
]}

机构：

[1] Univ Ulsan, Dept Biol Sci, Ulsan 680749, South Korea

[2] Gyeongsang Natl Univ, Sch Med, Dept Pathol, Jinju, South Korea

[3] Gyeongsang Natl Univ, Sch Med, Dept Anat, Jinju, South Korea

[4] Gyeongsang Natl Univ, Inst Hlth Sci, Jinju, South Korea

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2015年 / 185卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

TUMOR-NECROSIS-FACTOR; MESSENGER-RNA STABILITY; RESPIRATORY-DISTRESS-SYNDROME; PROTEIN-KINASE PATHWAY; GENE-EXPRESSION; FACTOR-ALPHA; POSTTRANSCRIPTIONAL REGULATION; STIMULATED MACROPHAGES; INFLAMMATION; DISEASE;

D O I：

10.1016/j.ajpath.2015.07.002

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Low-dose inhaled carbon monoxide is reported to suppress inflammatory responses and exhibit a therapeutic effect in models of lipopolysaccharide (LPS)-induced acute lung injury (ALI). However, the precise mechanism by which carbon monoxide confers protection against ALI is not clear. Tristetraprolin (UP; official name ZFP36) exerts anti-inflammatory effects by enhancing decay of proinflammatory cytokine mRNAs. With the use of TIP knockout mice, we demonstrate here that the protection by carbon monoxide against LPS-induced ALT is mediated by UP. Inhalation of carbon monoxide substantially increased the pulmonary expression of TTP. carbon monoxide markedly enhanced the decay of mRNA-encoding inflammatory cytokines, blocked the expression of inflammatory cytokines, and decreased tissue damage in LPS-treated lung tissue. Moreover, knockout of TIP abrogated the anti-inflammatory and tissue-protective effects of carbon monoxide in LPS-induced ALT. These results suggest that carbon monoxide-induced TTP mediates the protective effect of carbon monoxide against LPS-induced ALI by enhancing the decay of mRNA encoding proinflammatory cytokines.

引用

页码：2867 / 2874

页数：8

共 46 条

[1] Carbon monoxide orchestrates a protective response through PPARγ [J].