Gene Context and DNA Rearrangements in the Carbapenemase Locus of Division II Strains of Bacteroides fragilis

被引：9

作者：

Garcia, Nuria ^{[2
]}

Gutierrez, Gloria ^{[1
]}

Lorenzo, Maria ^{[2
]}

Vadillo, Santiago ^{[2
]}

Piriz, Segundo ^{[2
]}

Quesada, Alberto ^{[1
]}

机构：

[1] Univ Extremadura, Dept Bioquim, Fac Vet, Caceres 10071, Spain

[2] Univ Extremadura, Dept Sanidad Anim, Fac Vet, Caceres 10071, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 06期

关键词：

ELEMENTS; CFIA;

D O I：

10.1128/AAC.01514-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The cfiA gene is clustered in a bicistronic operon encoding an N-acetyltransferase and an O-acetyltransferase related to resistance markers. This genetic context, exclusively found in strains of Bacteroides fragilis division II, has been highly rearranged by the successive integration of two new mobile sequences, a miniature element and ISBf9. Besides that, among the DNA polymorphisms detected in the cfiA locus, only the integration of IS942 at its promoter was a determinant for expression of carbapenemase activity.

引用

页码：2677 / 2678

页数：2

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