Gene Context and DNA Rearrangements in the Carbapenemase Locus of Division II Strains of Bacteroides fragilis

被引:9
作者
Garcia, Nuria [2 ]
Gutierrez, Gloria [1 ]
Lorenzo, Maria [2 ]
Vadillo, Santiago [2 ]
Piriz, Segundo [2 ]
Quesada, Alberto [1 ]
机构
[1] Univ Extremadura, Dept Bioquim, Fac Vet, Caceres 10071, Spain
[2] Univ Extremadura, Dept Sanidad Anim, Fac Vet, Caceres 10071, Spain
关键词
ELEMENTS; CFIA;
D O I
10.1128/AAC.01514-08
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The cfiA gene is clustered in a bicistronic operon encoding an N-acetyltransferase and an O-acetyltransferase related to resistance markers. This genetic context, exclusively found in strains of Bacteroides fragilis division II, has been highly rearranged by the successive integration of two new mobile sequences, a miniature element and ISBf9. Besides that, among the DNA polymorphisms detected in the cfiA locus, only the integration of IS942 at its promoter was a determinant for expression of carbapenemase activity.
引用
收藏
页码:2677 / 2678
页数:2
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