Prevalence of Myositis-Specific Antibodies in Idiopathic Interstitial Pneumonias

被引：16
作者：
De Sadeleer, Laurens J. [1 ,2 ]
De langhe, Ellen [3 ,4 ]
Bodart, Nicolas [5 ]
Vigneron, Alain [5 ]
Bossuyt, Xavier [6 ,7 ]
Wuyts, Wim A. [1 ,2 ]
机构：
[1] Univ Hosp Leuven UZ Leuven, Dept Pneumol, Herestr 49, B-3000 Louvain, Belgium
[2] Katholieke Univ Leuven, Dept Chron Dis Metab & Ageing CHROMETA, Lab Pneumol, Louvain, Belgium
[3] Univ Hosp Leuven UZ Leuven, Dept Rheumatol, Louvain, Belgium
[4] Katholieke Univ Leuven, Lab Tissue Homeostasis & Dis, Dept Dev & Regenerat, Louvain, Belgium
[5] D Tek SA, Mons, Belgium
[6] Univ Hosp Leuven UZ Leuven, Dept Lab Med, Immunol, Louvain, Belgium
[7] Katholieke Univ Leuven, Dept Microbiol & Immunol, Expt Lab Immunol, Louvain, Belgium
来源：
LUNG | 2018年 / 196卷 / 03期
关键词：
Interstitial lung diseases; Myositis-specific antibodies; Connective tissue disease-related lung disease; Interstitial pneumonia with auto-immune features; LUNG-DISEASE; INFLAMMATORY MYOPATHIES; DERMATOMYOSITIS; POLYMYOSITIS;
D O I：
10.1007/s00408-018-0108-8
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Although included in the serological domain of the 'interstitial pneumonia with auto-immune features' (IPAF) research statement, the search for myositis-specific antibodies (MSA) is not incorporated in routine clinical practice. The objective of the study was to evaluate MSA prevalence in an idiopathic interstitial pneumonia (IIP) cohort (n = 68) with suggestive morphological interstitial lung disease patterns. Twelve of 68 patients (17.6%) carried MSA, whereof only two were antinuclear antibody-positive. Besides female gender, no demographic or pulmonary function parameter was predictive for MSA positivity. MSA were present in 32.4% of IPAF patients (n = 37), being essential for IPAF diagnosis in four of them (10.8%).
引用
收藏
页码：329 / 333
页数：5
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