A FUT2 Gene Common Polymorphism Determines Resistance to Rotavirus A of the P[8] Genotype

被引：115

作者：

Imbert-Marcille, Berthe-Marie ^{[1
,2
]}

Barbe, Laure ^{[3
]}

Dupe, Mathilde ^{[1
,2
]}

Le Moullac-Vaidye, Beatrice ^{[3
]}

Besse, Bernard ^{[1
,2
]}

Peltier, Cecile ^{[1
,2
]}

Ruvoen-Clouet, Nathalie ^{[3
,4
]}

Le Pendu, Jacques ^{[3
]}

机构：

[1] Univ Nantes, CHU Nantes, Serv Virol, F-44007 Nantes 1, France

[2] Univ Nantes, UPRES EA4271, F-44007 Nantes 1, France

[3] Univ Nantes, CNRS, INSERM, U892,UMR6299, F-44007 Nantes 1, France

[4] Oniris, Ecole Natl Vet Agroalimentaire & Alimentat, Nantes, France

来源：

JOURNAL OF INFECTIOUS DISEASES | 2014年 / 209卷 / 08期

关键词：

FUT2; histo-blood group antigens; ligands; rotavirus; secretor phenotype; BLOOD GROUP ANTIGENS; VP8(STAR); ATTACHMENT;

D O I：

10.1093/infdis/jit655

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Attachment to carbohydrates of the histo-blood group type of several human Rotavirus strains (RVA) has recently been described. Synthesis of these ligands requires a functional FUT2 enzyme, suggesting that FUT2 null homozygote (ie, nonsecretor) individuals may not be recognized by most human RVA strains. Whereas such individuals represent 20% of the control population, this retrospective study determined that none of 51 patients infected by P[8] rotavirus strains were nonsecretors. The lack of alpha 1,2fucosylated carbohydrate motifs in the gut surface mucosa is thus associated with resistance to symptomatic infection and virus attachment to such motifs is essential to the infection process.

引用

页码：1227 / 1230

页数：4

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