Surface Decorated Porphyrinic Nanoscale Metal Organic Framework for Photodynamic Therapy

被引：77

作者：

Kan, Jing-Lan ^{[1
]}

Jiang, Yuan ^{[1
]}

Xue, Anqi ^{[2
]}

Yu, Ying-Hao ^{[1
]}

Wang, Quanbo ^{[2
]}

Zhou, Yang ^{[1
]}

Dong, Yu-Bin ^{[1
]}

机构：

[1] Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Collaborat Innovat Ctr Functionalized Probes Chem, Key Lab Mol & Nano Probes,Minist Educ, Jinan 250014, Shandong, Peoples R China

[2] Qilu Univ Technol, Shandong Anal & Test Ctr, Shandong Acad Sci, Jinan 250014, Shandong, Peoples R China

来源：

INORGANIC CHEMISTRY | 2018年 / 57卷 / 09期

关键词：

SINGLET OXYGEN; CANCER; COMPLEXES; GENERATION; LIGAND; NANOMEDICINE; CHEMISTRY; THIOETHER; GOLD;

D O I：

10.1021/acs.inorgchem.8b00384

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Nanocrystallization of organic molecular photosensitizers (PSs) by means of NMOF platforms has been demonstrated to be a promising approach to build up highly efficient PDT therapeutics. We report herein a new UiO-66 type of NMOF-based PS (UiO-66-TPP-SH), which is generated from UiO-66 NMOF and S-ethylthiol ester monosubstituted metal free porphyrin (TPP-SH) via a facile postsynthetic approach under mild conditions. The obtained NMOF (size less than 150 nm) with surface-decorated porphyrinic PS can not only retain MOF crystallinity, structural feature, and size, but also exhibit highly efficient singlet oxygen generation. Compared to the interior-located porphyrinic NMOF, UiO-66TPP-SH shows significantly higher photodynamic activity and more efficient PDT tumor treatment.

引用

页码：5420 / 5428

页数：9

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