Accelerated Restoration of Ocular Surface Health in Dry Eye Disease by Self-Retained Cryopreserved Amniotic Membrane

被引：1
作者：
Cheng, Anny M. S. [1 ,2 ]
Zhao, Dandan [3 ]
Chen, Rendian [4 ]
Yin, Han Y. [5 ]
Tighe, Sean [1 ,2 ]
Sheha, Hosam [1 ,2 ]
Casas, Victoria [1 ,2 ]
Tseng, Scheffer C. G. [1 ,2 ]
机构：
[1] Ocular Surface Ctr, Miami, FL 33173 USA
[2] Tissuetech Inc, Miami, FL USA
[3] YanAn Hosp Kunming City, Dept Ophthalmol, Kunming, Yunnan, Peoples R China
[4] Shenzhen Childrens Hosp, Dept Ophthalmol, Guangzhou, Guangdong, Peoples R China
[5] Florida Int Univ, Herbert Wertheim Coll Med, Miami, FL 33199 USA
来源：
OCULAR SURFACE | 2016年 / 14卷 / 01期
关键词：
amniotic membrane; dry eye; keratitis; ocular surface; PROKERA (R); STEM-CELL DEFICIENCY; ACTIVATED MACROPHAGES; STROMAL MATRIX; WORKSHOP; 2007; TRANSPLANTATION; CORNEAL; SUPPRESSION; KERATITIS; DISORDERS; APOPTOSIS;
D O I：
暂无
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Purpose: To evaluate the clinical efficacy of self-retained cryopreserved amniotic membrane in treating dry eye disease. Methods: Retrospective review of 10 patients treated with self-retained cryopreserved amniotic membrane (PROKERA (R) Slim [PKS], Bio-Tissue, Miami, FL) for moderate-to-severe dry eye refractory to conventional maximal medical treatments. Patients' symptoms, use of medications, conjunctival inflammation, corneal staining, and visual acuity were compared before and after treatment. Results: PKS was placed in 15 eyes of the 10 patients for 4.9 +/- 1.5 days. All patients experienced symptomatic relief for a period of 4.2 +/- 4.7 months (P<.001). Such improvement was accompanied by reduction of OSDI scores (P<.001), use of topical medications (P<.001), conjunctival hyperemia (P<.001), corneal staining (P<.001), and improvement of the visual acuity (P=.06). Linear regression analysis estimated that the optimal duration of PKS placement was 5 days to achieve an average symptom-free duration of 4 months in patients with dry eye. Surprisingly, PKS placement also generated improvement in the contralateral eyes. Conclusion: This pilot study suggests that self-retained cryopreserved amniotic membrane via PKS can be used to treat moderate dry eye diseases and warrants further prospective controlled studies.
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收藏
页码：56 / 63
页数：8
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