Formal Total Synthesis of N-Methylmaysenine

被引：27
作者：
Wang, Lin
Gong, Jianxian
Deng, Lujiang
Xiang, Zheng
Chen, Zhixing
Wang, Yuefan
Chen, Jiahua [1 ]
Yang, Zhen
机构：
[1] Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Beijing 100871, Peoples R China
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 08期
基金：
美国国家科学基金会;
关键词：
OLEFIN-METATHESIS CATALYSTS; STEREOCONTROLLED TOTAL SYNTHESIS; MAYTANSINE; EFFICIENT; (&/-)-MAYTANSINOL; (-)-MAYTANSINOL; DEHYDRATION; INHIBITOR; REAGENT; FACILE;
D O I：
10.1021/ol900384u
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel synthetic approach for the formal total synthesis of N-methylmaysenine (1) has been developed. Key steps involve the Ti-mediated vinylogous Mukaiyama aldol reaction of chiral ketene silyl N,O-acetal with beta-dithiane-substituted aldehyde, an aldol condensation, and a ring-closing metathesis reaction.
引用
收藏
页码：1809 / 1812
页数：4
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