Effect of Left Ventricular Assist Device Implantation and Heart Transplantation on Habitual Physical Activity and Quality of Life

被引:57
作者
Jakovljevic, Djordje G. [1 ]
McDiarmid, Adam [3 ]
Hallsworth, Kate [1 ]
Seferovic, Petar M. [4 ]
Ninkovic, Vladan M. [5 ]
Parry, Gareth [6 ,7 ]
Schueler, Stephan [6 ,7 ]
Trenell, Michael I. [1 ]
MacGowan, Guy A. [2 ,3 ]
机构
[1] Newcastle Univ, Fac Med Sci, Inst Cellular Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[2] Newcastle Univ, Inst Genet Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[3] Freeman Rd Hosp, Dept Cardiol, Newcastle Upon Tyne, Tyne & Wear, England
[4] Univ Belgrade, Sch Med, Clin Ctr Serbia, Dept Cardiol, Belgrade, Serbia
[5] Specialist Hosp Merkur, Dept Cardiol, Vrnjacka Banja, Serbia
[6] Freeman Rd Hosp, Dept Cardiothorac Surg, Newcastle Upon Tyne, Tyne & Wear, England
[7] Freeman Rd Hosp, Dept Transplantat, Newcastle Upon Tyne, Tyne & Wear, England
关键词
EXERCISE PERFORMANCE; FUNCTIONAL-CAPACITY; ENERGY-EXPENDITURE; FAILURE; IMPACT; TRIAL;
D O I
10.1016/j.amjcard.2014.04.008
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The present study defined the short- and long-term effects of left ventricular assist device (LVAD) implantation and heart transplantation (HT) on physical activity and quality of life (QoL). Forty patients (LVAD, n = 14; HT, n = 12; and heart failure [HF], n = 14) and 14 matched healthy subjects were assessed for physical activity, energy expenditure, and QoL. The LVAD and HT groups were assessed postoperatively at 4 to 6 weeks (baseline) and 3, 6, and 12 months. At baseline, LVAD, HT, and HF patients demonstrated low physical activity, reaching only 15%, 28%, and 51% of that of healthy subjects (1,603 +/- 302 vs 3,036 +/- 439 vs 5,490 +/- 1,058 vs 10,756 +/- 568 steps/day, respectively, p <0.01). This was associated with reduced energy expenditure and increased sedentary time (p <0.01). Baseline QoL was not different among LVAD, HT, and RE groups (p = 0.44). LVAD implantation and HT significantly increased daily physical activity by 60% and 52%, respectively, from baseline to 3 months (p <0.05), but the level of activity remained unchanged at 3, 6, and 12 months. The QoL improved from baseline to 3 months in LVAD implantation and HT groups (p <0.01) but remained unchanged afterward. At any time point, HT demonstrated higher activity level than LVAD implantation (p <0.05), and this was associated with better QoL. In contrast, physical activity and QoL decreased at 12 months in patients with HF (p <0.05). In conclusion, patients in LVAD and HT patients demonstrate improved physical activity and QoL within the first 3 months after surgery, but physical activity and QoL remain unchanged afterward and well below that of healthy subjects. Strategies targeting low levels of physical activity should now be explored to improve recovery of these patients. (C) 2014 The Authors. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:88 / 93
页数:6
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