Synthesis of 1-[3-(Hetaryl)allyl]morpholines as Potential Anticholinesterase Agents

被引：2

作者：

Chernov, N. M. ^{[1
]}

Ezhov, P. I. ^{[1
]}

Shutov, R. V. ^{[1
]}

Yakovlev, I. P. ^{[1
]}

机构：

[1] St Petersburg State Chem Pharmaceut Univ, St Petersburg 197376, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2020年 / 90卷 / 09期

关键词：

chromone; allylamine; morpholine; pyrazole; pyrimidine; anticholinesterase activity; CHROMONE;

D O I：

10.1134/S1070363220090054

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A number of new pyrazole and pyrimidine derivatives containing an allylmorpholine fragment were obtained by reactions of chromone-containing allylmorpholines with 1,2- and 1,3-binucleophiles (hydrazine, guanidine, acetamidine). The syntheses were carried out under mild conditions (ethanol, room temperature), and the target products were isolated with high yields. The obtained compounds are of interest as potential cholinesterase inhibitors.

引用

页码：1620 / 1624

页数：5

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