SPECIFIC ACTIVITIES OF INDIVIDUAL c-Jun N-TERMINAL KINASES IN THE BRAIN

被引：87
作者：
Haeusgen, W. [1 ]
Boehm, R. [1 ]
Zhao, Y. [1 ]
Herdegen, T. [1 ]
Waetzig, V. [1 ]
机构：
[1] Univ Hosp Schleswig Holstein UK SH, Inst Expt & Clin Pharmacol, D-24105 Kiel, Germany
来源：
NEUROSCIENCE | 2009年 / 161卷 / 04期
关键词：
JNK; brain; regeneration; signalosome; neurodegeneration; signaling; ACTIVATED PROTEIN-KINASE; SIGNAL-TRANSDUCTION PATHWAY; CEREBELLAR GRANULE NEURONS; JNK INHIBITOR; CEREBRAL-ISCHEMIA; NEURITE OUTGROWTH; CORTICAL-NEURONS; PC12; CELLS; OXIDATIVE STRESS; SENSORY NEURONS;
D O I：
10.1016/j.neuroscience.2009.04.014
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The c-Jun N-terminal kinases (JNKs) are multifunctional molecules which, on the one hand, regulate various processes in brain development, repair and memory formation. On the other hand, JNKs are potent effectors of neuronal death and neuroinflammation. This review summarizes recent findings on individual JNK functions in the nervous system under pathophysiological conditions and on their regulation by upstream kinases, phosphatases and formation of context-dependent signalosomes. By focusing on different aspects of JNK signaling, it becomes increasingly obvious that the JNK cascade is intricately regulated and intensely dependent on the availability and functionality of its single components and their intracellular localization. Our review also emphasizes, that JNKs are indispensable for neuronal cell death as well as many physiological functions in the brain. Finally, we discuss pharmacological strategies which target pathological JNK activities without affecting their physiological functions. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：951 / 959
页数：9
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