Inhibitory activity of cyanidin-3-rutinoside on α-glucosidase

被引：38
作者：
Adisakwattana, S
Ngamrojanavanich, N
Kalampakorn, K
Tiravanit, W
Roengsumran, S
Yibchok-Anun, S [1 ]
机构：
[1] Chulalongkorn Univ, Fac Vet Sci, Dept Pharmacol, Bangkok 10330, Thailand
[2] Chulalongkorn Univ, Fac Sci, Dept Chem, Res Ctr Bioorgan Chem, Bangkok 10330, Thailand
来源：
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2004年 / 19卷 / 04期
关键词：
cyanidin-3-rutinoside; alpha-glucosidase inhibition; enzyme kinetics;
D O I：
10.1080/14756360409162443
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cyanidin-3-rutinoside, a natural anthocyanin, inhibited alpha-glucosidase from baker's yeast in dose-responsive manner. The IC50 value was 19.7 muM +/-0.24 muM, compared with the IC50 value of voglibose (IC50=23.4+/-0.30 muM). Cyanidin-3-rutinoside was found to be a non-competitive inhibitor for yeast alpha-glucosidase with a K-i value in the range of 1.31-1.56x10(-5) M. These results indicated that cyanidin-3-rutinoside could be classed as a new alpha-glucosidase inhibitor.
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页码：313 / 316
页数：4
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