Retinal Microvascular Network and Microcirculation Assessments in High Myopia

被引:175
作者
Li, Min [1 ,2 ]
Yang, Ye [2 ,4 ]
Jiang, Hong [2 ,3 ]
Gregori, Giovanni [2 ]
Roisman, Luiz [2 ]
Zheng, Fang [2 ]
Ke, Bilian [1 ]
Qu, Dongyi [2 ]
Wang, Jianhua [2 ]
机构
[1] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Ophthalmol, Sch Med, Shanghai, Peoples R China
[2] Univ Miami, Miller Sch Med, Bascom Palmer Eye Inst, Dept Ophthalmol, Miami, FL 33136 USA
[3] Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA
[4] Wenzhou Med Univ, Sch Optometry & Ophthalmol, Wenzhou, Peoples R China
基金
美国国家卫生研究院;
关键词
BLOOD-FLOW-VELOCITY; ENDOTHELIAL GROWTH-FACTOR; IN-VIVO CHARACTERIZATION; OPTIC DISC SIZE; FRACTAL ANALYSIS; VASCULAR NETWORK; FUNCTION IMAGER; AXIAL LENGTH; ANGIOGRAPHY; RETINOPATHY;
D O I
10.1016/j.ajo.2016.10.018
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
PURPOSE: To investigate the changes of the retinal microvascular network and microcirculation in high myopia. DESIGN: A cross-sectional, matched, comparative clinical study. PARTICIPANTS: Twenty eyes of 20 subjects with nonpathological high myopia (28 +/- 5 years of age) with a refractive error of -6.31 +/- 1.23 D (mean +/- SD) and 20 eyes of 20 age- and sex-matched control subjects (30 6 years of age) with a refractive error of -1.40 +/- 1.00 D were recruited. METHODS: Optical coherence tomography angiography (OCTA) was used to image the retinal microvascular network, which was later quantified by fractal analysis (box counting [D-box], representing vessel density) in both superficial and deep vascular plexuses. The Retinal Function Imager was used to image the retinal microvessel blood flow velocity (BFV). The BFV and microvascular density in the myopia group were corrected for ocular magnification using Bennett's formula. RESULTS: The density of both superficial and deep microvascular plexuses was significantly decreased in the myopia group in comparison to the controls (P < .05). The decrease of the microvessel density of the annular zone (0.6-2.5 mm), measured as Dbox, was 2.1% and 2.9% in the superficial and deep vascular plexuses, respectively. Microvessel density reached a plateau from 0.5 mm to 1.25 mm from the fovea in both groups, but that in the myopic group was about 3% lower than the control group. No significant differences were detected between the groups in retinal microvascular BFV in either arterioles or venules (P > .05). Microvascular densities in both superficial (r = -0.45, P = .047) and deep (r = -0.54, P = .01) vascular plexuses were negatively correlated with the axial lengths in the myopic eye. No, correlations were observed between BFV and vessel density (P > .05). CONCLUSIONS: Retinal microvascular decrease was observed in the high myopia subjects, whereas the retinal microvessel BFV remained unchanged. The retinal micro vascular network alteration may be attributed to ocular elongation that occurs with the progression of myopia. The novel quantitative analyses of the retinal microvasculature may help to characterize the underlying pathophysiology of myopia and enable early detection and prevention of myopic retinopathy. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码:56 / 67
页数:12
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