Anti-microbial Effects In Vitro and In Vivo of Alstonia scholaris

被引：16

作者：

Zhao, Yun-Li ^{[1
,2
,3
,4
]}

Gou, Zhong-Ping ^{[5
]}

Shang, Jian-Hua ^{[2
,3
,4
]}

Li, Wan-Yi ^{[6
]}

Kuang, Yu ^{[6
]}

Li, Ming-Yuan ^{[6
]}

Luo, Xiao-Dong ^{[1
,2
,3
,4
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[2] Yunnan Univ, Key Lab Med Chem Nat Resource, Minist Educ, Kunming 650091, Yunnan, Peoples R China

[3] Yunnan Univ, Yunnan Prov Ctr Res & Dev Nat Prod, Kunming 650091, Yunnan, Peoples R China

[4] Yunnan Univ, Sch Chem Sci & Technol, Kunming 650091, Yunnan, Peoples R China

[5] Sichuan Univ, Inst Drug Clin Trials, West China Hosp, Chengdu 610041, Peoples R China

[6] Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Chengdu 610041, Peoples R China

来源：

NATURAL PRODUCTS AND BIOPROSPECTING | 2021年 / 11卷 / 01期

关键词：

Alstonia scholaris; Total alkaloids; Acute respiratory infections; Anti-virus; Anti-bacteria; MONOTERPENOID INDOLE ALKALOIDS; FLIGHT MASS-SPECTROMETRY; ANTIBACTERIAL ACTIVITY; BARK EXTRACTS; LEAVES; LEAF; IDENTIFICATION; CONSTITUENTS; INFECTIONS; H1N1;

D O I：

10.1007/s13659-020-00294-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Alstonia scholaris could be used as a traditional medicinal plant in China for the treatment of acute respiratory, which might be caused by respiratory tract infections. The investigation tested the anti-infective effects of total alkaloids extract (TA) from leaves of A. scholaris, and as a result, TA inhibited herpes simplex virus type 1 (HSV-1), respiratory syncytial virus (RSV) and influenza A virus (H1N1) in vitro respectively. In addition, the survival days of mice were prolonged, and the lung weights and mortality of mice were decreased significantly, after oral administrated TA in H1N1 and beta-hemolytic streptococcus infectious models in vivo respectively. The finding supported partly the traditional usage of A. scholaris in the treatment of respiratory infections. [GRAPHICS] .

引用

页码：127 / 135

页数：9

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