Pegaharmalines A and B, two novel β-carboline alkaloids with unprecedented carbon skeletons from Peganum harmala

被引：44

作者：

Wang, Kai-Bo ^{[1
]}

Yuan, Chun-Mao ^{[2
]}

Xue, Chun-Mei ^{[1
]}

Li, Da-Hong ^{[1
]}

Jing, Yong-Kui ^{[3
]}

He, Hong-Ping ^{[2
]}

Hao, Xiao-Jiang ^{[2
]}

Di, Ying-Tong ^{[2
]}

Li, Zhan-Lin ^{[1
]}

Hua, Hui-Ming ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China

[3] Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA

来源：

RSC ADVANCES | 2014年 / 4卷 / 96期

基金：

中国国家自然科学基金;

关键词：

SCAFFOLD; ROOTS; MODES;

D O I：

10.1039/c4ra07985j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pegaharmalines A (1) and B (2), two novel beta-carboline alkaloids with unprecedented carbon skeletons, were isolated from the seeds of Peganum harmala. Their structures were determined by spectroscopic methods and the absolute configuration of 1 was elucidated by CD analysis. 1 and 2 exhibited significant cytotoxicities on HL-60 cells with IC50 values of 9.4 and 13.6 mu M, respectively.

引用

页码：53725 / 53729

页数：5

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