Four new members expand the interleukin-1 superfamily

被引：289

作者：

Smith, DE ^{[1
]}

Renshaw, BR ^{[1
]}

Ketchem, RR ^{[1
]}

Kubin, M ^{[1
]}

Garka, KE ^{[1
]}

Sims, JE ^{[1
]}

机构：

[1] Immunex Corp, Seattle, WA 98101 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2000年 / 275卷 / 02期

关键词：

D O I：

10.1074/jbc.275.2.1169

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report here the cloning and characterization of four new members of the interleukin-1 (IL-1) family (FIL1 delta, FIL1 epsilon, FIL1 zeta and FLI1 eta, with FIL1 standing for "Family of IL-1"), The novel genes demonstrate significant sequence similarity to IL-1 alpha, IL-1 beta, IL-1ra, and IL-18, and in addition maintain a conserved exon-intron arrangement that is shared with the previously known members of the family. Protein structure modeling also suggests that the FIL1 genes are related to IL-1 beta and IL-1ra. The novel genes form a cluster with the IL-1s on the long arm of human chromosome 2.

引用

页码：1169 / 1175

页数：7

共 42 条

[1] A newly defined interleukin-1? [J].

Bazan, JF ;

Timans, JC ;

Kastelein, RA .

NATURE, 1996, 379 (6566) :591-591

[2] PROTEIN DATA BANK - COMPUTER-BASED ARCHIVAL FILE FOR MACROMOLECULAR STRUCTURES [J].

BERNSTEIN, FC ;

KOETZLE, TF ;

WILLIAMS, GJB ;

MEYER, EF ;

BRICE, MD ;

RODGERS, JR ;

KENNARD, O ;

SHIMANOUCHI, T ;

TASUMI, M .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1977, 80 (02) :319-324

[3] Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling [J].

Born, TL ;

Thomassen, E ;

Bird, TA ;

Sims, JE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (45) :29445-29450

[4] MOLECULAR-CLONING OF THE INTERLEUKIN-1-BETA CONVERTING ENZYME [J].

CERRETTI, DP ;

KOZLOSKY, CJ ;

MOSLEY, B ;

NELSON, N ;

VANNESS, K ;

GREENSTREET, TA ;

MARCH, CJ ;

KRONHEIM, SR ;

DRUCK, T ;

CANNIZZARO, LA ;

HUEBNER, K ;

BLACK, RA .

SCIENCE, 1992, 256 (5053) :97-100

[5] THE TYPE-II DECOY RECEPTOR - A NOVEL REGULATORY PATHWAY FOR INTERLEUKIN-1 [J].

COLOTTA, F ;

DOWER, SK ;

SIMS, JE ;

MANTOVANI, A .

IMMUNOLOGY TODAY, 1994, 15 (12) :562-566

[6] INTERLEUKIN-1 TYPE-II RECEPTOR - A DECOY TARGET FOR IL-1 THAT IS REGULATED BY IL-4 [J].

COLOTTA, F ;

RE, F ;

MUZIO, M ;

BERTINI, R ;

POLENTARUTTI, N ;

SIRONI, M ;

GIRI, JG ;

DOWER, SK ;

SIMS, JE ;

MANTOVANI, A .

SCIENCE, 1993, 261 (5120) :472-475

[7] CLONING, SEQUENCE AND EXPRESSION OF HUMAN INTERLEUKIN-2 RECEPTOR [J].

COSMAN, D ;

CERRETTI, DP ;

LARSEN, A ;

PARK, L ;

MARCH, C ;

DOWER, S ;

GILLIS, S ;

URDAL, D .

NATURE, 1984, 312 (5996) :768-771

[8]

Cullinan EB, 1998, J IMMUNOL, V161, P5614

[9]

Dinarello C A, 1998, Int Rev Immunol, V16, P457, DOI 10.3109/08830189809043005

[10] Overview of interleukin-18:: more than an interferon-γ inducing factor [J].

Dinarello, CA ;

Novick, D ;

Puren, AJ ;

Fantuzzi, G ;

Shapiro, L ;

Mühl, H ;

Yoon, DY ;

Reznikov, LL ;

Kim, SH ;

Rubinstein, M .

JOURNAL OF LEUKOCYTE BIOLOGY, 1998, 63 (06) :658-664

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