Maternal supplementation with n-3 long chain polyunsaturated fatty acids during perinatal period alleviates the metabolic syndrome disturbances in adult hamster pups fed a high-fat diet after weaning

被引:11
作者
Kasbi-Chadli, Fatima [1 ,2 ,3 ]
Boquien, Clair-Yves [1 ,3 ]
Simard, Gilles [4 ]
Ulmann, Lionel [5 ]
Mimouni, Virginie [5 ]
Leray, Veronique [2 ,3 ]
Meynier, Anne [6 ]
Ferchaud-Roucher, Veronique [1 ,3 ]
Champ, Martine [1 ,3 ]
Nguyen, Patrick [2 ,3 ]
Ouguerram, Khadija [1 ,3 ]
机构
[1] CHU Hotel Dieu, INRA, UMR 1280, F-44000 Nantes, France
[2] LUNAM Univ, Natl Coll Vet Med Food Sci & Engn, Endocrinol & Nutr Unit, F-44307 Nantes, France
[3] CHU Hotel Dieu, CRNH, Western Human Nutr Res Ctr, F-44093 Nantes, France
[4] IBS IRIS, NSERM U1063, F-49045 Angers, France
[5] LUNAM Univ, IUT Dept Genie Biol, EA 2160, F-53020 Laval, France
[6] INRA, Biopolymeres Interact Assemblages UR1268, F-44316 Nantes, France
关键词
Perinatal nutrition; n-3; LC-PUFA; Metabolic syndrome; Mitochondrial function; Hamster; HUMAN SKELETAL-MUSCLE; INSULIN-RESISTANCE; APOLIPOPROTEIN-B; DOCOSAHEXAENOIC ACID; ADIPOSE-TISSUE; PREGNANCY; PLASMA; OXIDATION; OBESITY; RATS;
D O I
10.1016/j.jnutbio.2014.03.003
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Perinatal nutrition is thought to affect the long-term risk of the adult to develop metabolic syndrome. We hypothesized that maternal supplementation with eicosapentaenoic acid and docosahexaenoic acid during pregnancy and lactation would protect offspring fed a high-fat diet from developing metabolic disturbances. Thus, two groups of female hamsters were fed a low-fat control diet, either alone (LC) or enriched with n-3 long chain polyunsaturated fatty acids (LC-PUFA) (LO), through the gestational and lactation periods. After weaning, male pups were randomized to separate groups that received either a control lowfat diet (LC) or a high-fat diet (HC) for 16 weeks. Four groups of pups were defined (LC-LC, LC-HC, LO-LC and LO-HC), based on the combinations of maternal and weaned diets. Maternal n-3 LC-PUFA supplementation was associated with reduced levels of basal plasma glucose, hepatic triglycerides secretion and postprandial lipemia in the LO-HC group compared to the LC-HC group. Respiratory parameters were not affected by maternal supplementation. In contrast, n-3 LC-PUFA supplementation significantly enhanced the activities of citrate synthase, isocitrate dehydrogenase and a-ketoglutarate dehydrogenase compared to the offspring of unsupplemented mothers. Sterol regulatory element binding protein-1c, diacylglycerol O-acyltransferase 2, fatty acid synthase, stearoyl CoA desaturase 1 and tumor necrosis factor a expression levels were not affected by n-3 LC-PUFA supplementation. These results provide evidence for a beneficial effect of n-3 LC-PUFA maternal supplementation in hamsters on the subsequent risk of metabolic syndrome. Underlying mechanisms may include improved lipid metabolism and activation of the mitochondrial oxidative pathway. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码:726 / 733
页数:8
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