Lesion with morphologic feature of organizing pneumonia (OP) in CT-guided lung biopsy samples for diagnosis of bronchiolitis obliterans organizing pneumonia (BOOP): a retrospective study of 134 cases in a single center

被引：16

作者：

Miao, Liyun ^{[1
,2
]}

Wang, Yongsheng ^{[1
]}

Li, Yan ^{[1
]}

Ding, Jingjing ^{[1
]}

Chen, Lulu ^{[1
]}

Dai, Jinghong ^{[1
]}

Cai, Hourong ^{[1
]}

Xiao, Yonglong ^{[1
]}

Cao, Min ^{[1
]}

Huang, Mei ^{[1
]}

Qiu, Yuying ^{[1
]}

Meng, Fanqing ^{[3
]}

Fan, Xiangshan ^{[3
]}

Zhang, Deping ^{[1
]}

Song, Yong ^{[2
]}

机构：

[1] Nanjing Univ, Sch Med, Nanjing Drum Tower Hosp, Dept Resp Med, Nanjing 210008, Jiangsu, Peoples R China

[2] Nanjing Univ, Sch Med, Jinling Hosp, Dept Resp Med, Nanjing 210002, Jiangsu, Peoples R China

[3] Nanjing Univ, Sch Med, Nanjing Drum Tower Hosp, Dept Pathol, Nanjing 210008, Jiangsu, Peoples R China

来源：

JOURNAL OF THORACIC DISEASE | 2014年 / 6卷 / 09期

关键词：

Bronchiolitis obliterans organizing pneumonia (BOOP); organizing pneumonia (OP); CT-guided lung biopsy; diagnosis; retrospective study; HIGH-RESOLUTION CT; IDIOPATHIC INTERSTITIAL PNEUMONIAS; COMPLICATION RATE; DISEASES;

D O I：

10.3978/j.issn.2072-1439.2014.08.23

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background: Small biopsy samples are generally considered inconclusive for bronchiolitis obliterans organizing pneumonia (BOOP) diagnosis despite their potential to reveal organizing pneumonia (OP) pathologically, necessitating risky invasive tissue biopsy during surgery for reliable confirmation. Objective: OP by CT-guided lung biopsy was to evaluate the role in the diagnosis of BOOP. Methods: A retrospective review of 134 cases with the OP feature in the CT-guided lung biopsy samples between 2004 and 2011 at a single center was conducted. Diagnostic accuracy of OP by CT-guided lung biopsy and clinical-radiographic data alone were compared. Results: After exclusion of 11 cases due to pathology with others besides OP and 15 cases for loss to follow-up, 108 were included. Of these, 95 cases and 13 cases were classified as BOOP and non-BOOP group, respectively. Among BOOP group, only 30 were initially diagnosed as BOOP according to the typical clinical and radiographic features. The other 65 cases with atypical features were diagnosed as BOOP mainly based on OP by CT-guided lung biopsy. Among non-BOOP group, one was misdiagnosed as BOOP, and others were not BOOP according to clinical and radiographic findings. Thus, OP by CT-guided lung biopsy produced a diagnostic accuracy of 87.96% (95/108), much higher than 31.25% (30/96) observed using clinical and radiographic data alone. Combined, these techniques produced diagnostic accuracy of 98.96% (95/96). Conclusions: OP by CT-guided lung biopsy can be effectively used as the pathological evidence for BOOP diagnosis and reducing unnecessary surgery.

引用

页码：1251 / 1260

页数：10

共 28 条

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