Synthesis of Indolizines from Pyridinium Salts and Ethyl Bromodifluoroacetate

被引：42

作者：

Hou, Xiaoya ^{[1
]}

Zhou, Sen ^{[1
]}

Li, Yuli ^{[1
]}

Guo, Minjie ^{[2
]}

Zhao, Wentao ^{[1
]}

Tang, Xiangyang ^{[1
]}

Wang, Guangwei ^{[1
]}

机构：

[1] Tianjin Univ, Sch Sci, Dept Chem, Tianjin Key Lab Mol Optoelect Sci, Tianjin 300072, Peoples R China

[2] Tianjin Univ, Sch Pharmaceut Sci & Technol, Inst Mol Design & Synth, Tianjin 300072, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 23期

关键词：

1,3-DIPOLAR CYCLOADDITION; FUNCTIONALIZED INDOLIZINES; DIRECT DIFLUOROMETHYLATION; DERIVATIVES; YLIDES; DIFLUOROALKYLATION; PHARMACEUTICALS; FLUORINE; ALCOHOLS; ALKENES;

D O I：

10.1021/acs.orglett.0c03540

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here we present a novel annulation of pyridinium salts with BrCF2CO2 Et to access the indolizine derivatives with high efficiency. The alpha substitution of pyridine plays a key role in determining the reaction pathways. Various types of indolizines can be conveniently accessed from easily available pyridinium salts under mild and simple reaction conditions.

引用

页码：9313 / 9318

页数：6

共 50 条

[1] INDOLIZINES .1. DIRECT SYNTHESIS OF ACYLINDOLIZINES FROM SUBSTITUTED PYRIDINIUM SALTS
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