Recent Advances in Synthesis of Benzazoles via Imines

被引:9
作者
An, Ran [1 ]
Gu, Mengbi [1 ]
Zang, Yingbo [1 ]
Xu, Hang [1 ]
Hou, Zhuang [1 ]
Guo, Chun [1 ]
机构
[1] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Minist Educ, Key Lab Struct Based Drugs Design & Discovery, Shenyang 110016, Peoples R China
基金
中国国家自然科学基金;
关键词
Imines; 1; 3-benzazoles; 2-benzazoles; oxidative/redox coupling reactions; synthetic methodologies; mechanisms; ONE-POT SYNTHESIS; N BOND FORMATIONS; 3 COMPONENT SYNTHESIS; C-N; 2-SUBSTITUTED BENZIMIDAZOLES; CONSECUTIVE CONDENSATION; SELECTIVE SYNTHESIS; AROMATIC DIAMINES; PRIMARY AMINES; OXIDE NANOPARTICLES;
D O I
10.2174/1385272824999200818180845
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Imines, versatile intermediates for organic synthesis, can be exploited for the preparation of diverse classes of biologically active benzazoles. Because of the special characteristics of the C=N bond, imines can be simultaneously used in the synthesis of 1,3-benzazoles and 1,2-benzazoles. With the development of imine synthesis, a variety of novel cascade reactions for benzazole synthesis have been reported in the last decade. Therefore, there is a strong need to elucidate the recent progress in the formation of various classes of benzazoles, including benzimidazoles, benzoxazoles, benzothiazoles, indazoles, and benzisoxazoles, via imines obtained by condensation reactions or oxidative/redox coupling reactions. In this review, we provide a comprehensive survey of this area. in particular, various green and mild synthetic methodologies are summarized, and the multiple roles of novel catalysts and significant mechanisms for several transformations are highlighted in detail. We believe that this review will aid researchers studying the synthesis of complex molecules containing the benzazole motif via imines.
引用
收藏
页码:1897 / 1942
页数:46
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