SYNTHESIS AND EVALUATION OF ANALGESIC, ANTI-INFLAMMATORY AND ANTI-BACTERIAL ACTIVITY OF SYNTHETIC PORPHYRIN DERIVATIVES

In this work porphyrins compounds (N1-N4) were synthesized from monohydroxy tetraphenylporphyrin, and then characterized on the basis of their chemical properties and spectral data. They were further tested for their potential analgesic and anti-inflammatory activities in acetic acid induced writhing test in mice and carrageenan induced paw edema in rats. The compounds were also evaluated for antibacterial activity in disc diffusion method. Compounds N1, N2 and N4 showed significant analgesic and anti-inflammatory activity at 10 and 30 mg/kg (b.w), comparable to the standard reference drugs. Furthermore, all the tested compounds possessed significant anti-bacterial activity against both gram positive and gram negative bacteria. The analgesic, anti-inflammatory and anti-bacterial activities of the tested compounds were found comparable to reference drugs. These compounds can serve as precursors for the development of clinically useful analgesics, anti-inflammatory and anti-bacterial agents.