Polyethylene glycol-grafted polystyrene particles

被引：61

作者：

Meng, FH ^{[1
]}

Engbers, GHM ^{[1
]}

Feijen, J ^{[1
]}

机构：

[1] Univ Twente, Inst Biomed Technol, Dept Chem Technol, Polymer Chem & Biomat Grp, NL-7500 AE Enschede, Netherlands

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2004年 / 70A卷 / 01期

关键词：

polystyrene particles; pegylation; carbodiimide; protein adsorption;

D O I：

10.1002/jbm.a.30056

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Densely pegylated particles that can serve as a model system for artificial cells were prepared by covalently grafting amino polyethylene glycol (PEG, molecular weight 3400 or 5000) onto carboxyl polystyrene particles (PS-COOH) using carbodiimide chemistry. PEG-modified particles (PS-PEG) were characterized by determination of the PEG surface concentration, C-potential, size, and morphology. Under optimized grafting conditions, a dense "brush-like" PEG layer was formed. A PEG surface concentration of approximately 60 pmol/cm(2), corresponding with an average distance between grafted PEG chains of similar to17 Angstrom can be realized. It was shown that grafting of PEG onto PS-COOH reduced the adsorption of proteins from human plasma (85 vol %) in phosphate-buffered saline up to 90%. (C) 2004 Wiley Periodicals, Inc.

引用

页码：49 / 58

页数：10

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