Enantioselective synthesis of functionalized fluorinated dihydropyrano [2,3-c]pyrazoles catalyzed by a simple bifunctional diaminocyclohexane-thiourea

被引：30
作者：
Zhang, Hong-Fei [1 ]
Ye, Zheng-Qing [1 ]
Zhao, Gang [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Subst, Shanghai 200032, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2014年 / 25卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Trifluoromethyl; Pyrazoles; Cyclization; Organocatalysis; ONE-POT SYNTHESIS; ASYMMETRIC MICHAEL ADDITION; NAD(+)-DEPENDENT DNA-LIGASE; CARBONYL-COMPOUNDS; DERIVATIVES; HALOGENATION; ACTIVATION; STRATEGIES; MICROWAVE; ANALOGS;
D O I：
10.1016/j.cclet.2014.01.034
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Enantioselective synthesis of functionalized fluorinated dihydropyrano[2,3-c]pyrazoles has been achieved via a diaminocyclohexane-thiourea catalyzed cascade Michael addition and Thorpe-Ziegler type cyclization in high yields (up to 98%) with moderate to good enantioselectivity (up to 90% ee). (C) 2014 Gang Zhao. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码：535 / 540
页数：6
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