Hepatoprotective effects of Lactobacillus plantarum C88 on LPS/D-GalN-induced acute liver injury in mice

被引：23
作者：
Duan, Cuicui [1 ]
Zhao, Yujuan [1 ]
Huang, Cheng [1 ]
Zhao, Zijian [1 ]
Gao, Lei [1 ]
Niu, Chunhua [1 ]
Wang, Chao [1 ]
Liu, Xiaoxiao [2 ]
Zhang, Chuan [3 ]
Li, Shengyu [1 ]
机构：
[1] Jilin Acad Agr Sci, Inst Agrofood Technol, 1363 Sheng Tai St, Changchun 130033, Jilin, Peoples R China
[2] Jilin Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Changchun 130033, Jilin, Peoples R China
[3] Jilin Univ, Dept Endocrinol, Hosp 2, Changchun 130000, Jilin, Peoples R China
来源：
JOURNAL OF FUNCTIONAL FOODS | 2018年 / 43卷
关键词：
Lactobacillus plantarum; Hepatoprotective; Antioxidation; Anti-inflammation; Intestinal barrier; NF-KAPPA-B; FULMINANT HEPATIC-FAILURE; EPITHELIAL BARRIER DYSFUNCTION; OXIDATIVE STRESS; INTESTINAL BARRIER; SIGNALING PATHWAY; INTERFERON-GAMMA; UP-REGULATION; MOUSE MODEL; CELLS;
D O I：
10.1016/j.jff.2018.02.005
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Acute liver failure (ALF) is a life-threatening clinical condition resulting from massive apoptosis of hepatocytes. This study aims to examine the protective effects of Lactobacillus plantanun C88 on LPS/D-GalN-induced ALF and elucidate its underlying molecular mechanisms in mice. The results showed that L. plantarum C88 pretreatment significantly reduced the levels of plasma ALT and AST in mice with LPS/D-GalN-induced liver injury. L. plantation C88 pretreatment decreased the secretion of inflammatory cytokines. In addition, L. plantarum C88 remarkably increased the expression levels and nuclear translocations of Nrf2 mRNA in liver tissues, but inhibited NF-kappa B nuclear translocations and P65, P38 phosphorylation levels. Moreover, L. plantarum C88 enhanced the intestinal mucosa] barrier by upregulating the expressions of tight junction proteins as well as HIF-1 alpha. These results suggest that L. plantarum C88 protects against ALF associated with Nrf2 and the MAPK/NF-kappa B signaling pathways.
引用
收藏
页码：146 / 153
页数：8
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