Oat beta-glucan ameliorates insulin resistance in mice fed on high-fat and high-fructose diet

被引：18

作者：

Zheng, Jie ^{[1
,2
]}

Shen, Nanhui ^{[2
]}

Wang, Shuanghui ^{[2
]}

Zhao, Guohua ^{[1
]}

机构：

[1] Southwest Univ, Coll Food Sci, Chongqing, Peoples R China

[2] Chongqing Univ, Dept Chem & Chem Engn, Chongqing 630044, Peoples R China

来源：

FOOD & NUTRITION RESEARCH | 2013年 / 57卷

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

oat beta-glucan; high-fat; high-fructose; insulin resistance; mice; GLUCOSE-HOMEOSTASIS; GLUCOKINASE GENE; PLASMA-GLUCOSE; BARLEY; RESPONSES; BRAN; CONSUMPTION; PRODUCTS; EXTRACTS; OBESITY;

D O I：

10.3402/fnr.v57i0.22754

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Methods: This study sought to evaluate the impact of oat beta-glucan on insulin resistance in mice fed on high-fat and high-fructose diet with fructose (10%, w/v) added in drinking water for 10 weeks. Results: The results showed that supplementation with oat beta-glucan could significantly reduce the insulin resistance both in low-dose (200 mg/kg(-1) body weight) and high-dose (500 mg/kg(-1) body weight) groups, but the high-dose group showed a more significant improvement in insulin resistance (P<0.01) compared with model control (MC) group along with significant improvement in hepatic glycogen level, oral glucose, and insulin tolerance. Moreover, hepatic glucokinase activity was markedly enhanced both in low-dose and high-dose groups compared with that of MC group (P<0.05). Conclusion: These results suggested that supplementation of oat beta-glucan alleviated insulin resistance and the effect was dose dependent.

引用

页数：7

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