Genetic association studies in obsessive-compulsive disorder

被引：0

作者：

Sampaio, Aline Santos ^{[1
,2
]}

Pacheco Lins, Rita Marcia ^{[3
]}

Daltro-Oliveira, Renato ^{[3
]}

Quarantini, Lucas de Castro ^{[3
,4
]}

do Rosario, Maria Conceicao ^{[5
]}

Miguel, Euripedes Constantino ^{[1
]}

Hounie, Ana Gabriela ^{[1
]}

机构：

[1] FMUSP, Dept & Inst Psiquiatria, Sao Paulo, Brazil

[2] Univ Fed Bahia UFBA, Serv Med Univ Dr Rubens Brasil, Salvador, BA, Brazil

[3] Univ Fed Bahia, Fac Med, Dept Neurociencias & Saude Mental, Salvador, BA, Brazil

[4] Univ Fed Bahia, Salvador, BA, Brazil

[5] Univ Fed Sao Paulo Unifesp, Dept Psiquiatria, Sao Paulo, Brazil

来源：

REVISTA DE PSIQUIATRIA CLINICA | 2013年 / 40卷 / 05期

关键词：

Association; gene; obsessive-compulsive disorder; review; CATECHOL-O-METHYLTRANSFERASE; FAMILY-BASED ASSOCIATION; 5-HT2A PROMOTER POLYMORPHISM; WHITE-MATTER ABNORMALITIES; SYSTEM CANDIDATE GENES; NECROSIS-FACTOR-ALPHA; SEROTONIN TRANSPORTER; RECEPTOR GENE; EARLY-ONSET; TOURETTE-SYNDROME;

D O I：

暂无

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: Obsessive-compulsive disorder (OCD) segregates in families. It follows a complex model of genetic transmission, which involves the influence of several small effect genes interacting with the environment. Methods: A systematic review of genetic association studies in OCD was performed. Articles published until 2012 were searched in the databases PubMed, Embase and SciELO using the terms of MeSH and its associates or synonyms for "obsessive-compulsive disorder", "gene" and "genetic association studies". Results: We selected 105 papers and described their main results grouped as genes related to: serotonin, dopamine, glutamate, GABA, white matter, immune system, hormones and other genes. Conclusion: There is high variability between findings of association studies among the several candidate genes studied in OCD. Glutamate-related genes are promising candidates for OCD, but there is no conclusive association between any of the candidate genes studied and OCD. Association studies with large sample size, evaluation of more homogeneous subgroups of phenotype and meta-analyses are still needed.

引用

页码：177 / 190

页数：14

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