In transit sentinel node drainage as a prognostic factor for patients with cutaneous melanoma

被引：2

作者：

Brandao, Paulo H. D. M. ^{[1
]}

Bertolli, Eduardo ^{[2
]}

Doria-Filho, Eduardo ^{[1
]}

Santos Filho, Ivan D. A. O. ^{[2
]}

de Macedo, Mariana P. ^{[3
]}

Pinto, Clovis A. L. ^{[3
]}

Duprat Neto, Joao P. ^{[2
]}

机构：

[1] AC Camargo Canc Ctr, Surg Oncol Med Residence Program, Sao Paulo, Brazil

[2] AC Camargo Canc Ctr, Skin Canc Dept, Rua Prof Antonio Prudente 211, BR-01509900 Sao Paulo, Brazil

[3] AC Camargo Canc Ctr, Pathol, Sao Paulo, Brazil

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2018年 / 117卷 / 05期

关键词：

in transit sentinel node; melanoma; sentinel lymph node; EARLY-STAGE MELANOMA; LYMPH-NODES; INTERVAL NODES; DISSECTION; BIOPSY; LYMPHOSCINTIGRAPHY; METASTASIS; EXPERIENCE;

D O I：

10.1002/jso.25023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundMinor basin or in transit node drainage can be found in patients with cutaneous melanoma who undergo sentinel node biopsy. Its clinical impact is still unclear. Our objective is to evaluate clinical outcomes in patients who presented with in transit sentinel node (ITN) drainage. Material and MethodsRetrospective analysis of patients who underwent sentinel node biopsy (SNB) in a single Brazilian institution between 2000 and 2015. ResultsOur cohort comprised 1223 SNB. There were 64 patients (5.2%) with ITN. Melanoma of the limbs (OR 10.61, P<0.0001) and acral subtype (OR 3.49, P<0.0001) were associated with ITN drainage. Among these 64 patients, 14 (21.9%) had a positive SNB. The ITN was positive for metastases in five patients, four in a popliteal basin and one on the trunk. Regarding completion node dissection (CND), two patients had positive non-sentinel nodes (NSN), both in major basins. In patients who developed recurrence, time to recurrence was shorter (mean time 18 vs 31.4 months, P=0.001) and time to death was shorter (mean time 31.6 vs 40 months, P=0.039) in those who had ITN drainage. ConclusionITN drainage was associated with earlier recurrences and deaths from melanoma.

引用

页码：864 / 867

页数：4

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