TiProD: the Tissue-specific Promoter Database

被引:24
作者
Chen, Xin
Wu, Jian-min
Hornischer, Klaus
Kel, Alexander
Wingender, Edgar [1 ]
机构
[1] Peking Univ, Natl Lab Prot Engn & Plant Genet Engn, Coll Life Sci, Ctr Bioinformat, Beijing 100871, Peoples R China
[2] BIOBASE GmbH, D-38304 Wolfenbuttel, Germany
[3] Univ Gottingen, UKG, Dept Bioinformat, D-37077 Gottingen, Germany
关键词
D O I
10.1093/nar/gkj113
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
TiProD is a database of human promoter sequences for which some functional features are known. It allows a user to query individual promoters and the expression pattern they mediate, gene expression signatures of individual tissues, and to retrieve sets of promoters according to their tissue-specific activity or according to individual Gene Ontology terms the corresponding genes are assigned to. We have defined a measure for tissue-specificity that allows the user to discriminate between ubiquitously and specifically expressed genes. The database is accessible at http://tiprod.cbi.pku.edu.cn:8080/index.html.
引用
收藏
页码:D104 / D107
页数:4
相关论文
共 18 条
[1]   Gene Ontology: tool for the unification of biology [J].
Ashburner, M ;
Ball, CA ;
Blake, JA ;
Botstein, D ;
Butler, H ;
Cherry, JM ;
Davis, AP ;
Dolinski, K ;
Dwight, SS ;
Eppig, JT ;
Harris, MA ;
Hill, DP ;
Issel-Tarver, L ;
Kasarskis, A ;
Lewis, S ;
Matese, JC ;
Richardson, JE ;
Ringwald, M ;
Rubin, GM ;
Sherlock, G .
NATURE GENETICS, 2000, 25 (01) :25-29
[2]   Searching for statistically significant regulatory modules [J].
Bailey, Timothy L. ;
Noble, William Stafford .
BIOINFORMATICS, 2003, 19 :II16-II25
[3]  
Frech K, 1998, In Silico Biol, V1, P29
[4]   Ensembl 2005 [J].
Hubbard, T ;
Andrews, D ;
Caccamo, M ;
Cameron, G ;
Chen, Y ;
Clamp, M ;
Clarke, L ;
Coates, G ;
Cox, T ;
Cunningham, F ;
Curwen, V ;
Cutts, T ;
Down, T ;
Durbin, R ;
Fernandez-Suarez, XM ;
Gilbert, J ;
Hammond, M ;
Herrero, J ;
Hotz, H ;
Howe, K ;
Iyer, V ;
Jekosch, K ;
Kahari, A ;
Kasprzyk, A ;
Keefe, D ;
Keenan, S ;
Kokocinsci, F ;
London, D ;
Longden, I ;
McVicker, G ;
Melsopp, C ;
Meidl, P ;
Potter, S ;
Proctor, G ;
Rae, M ;
Rios, D ;
Schuster, M ;
Searle, S ;
Severin, J ;
Slater, G ;
Smedley, D ;
Smith, J ;
Spooner, W ;
Stabenau, A ;
Stalker, J ;
Storey, R ;
Trevanion, S ;
Ureta-Vidal, A ;
Vogel, J ;
White, S .
NUCLEIC ACIDS RESEARCH, 2005, 33 :D447-D453
[5]   A novel computational approach for the prediction of networked transcription factors of aryl hydrocarbon-receptor-regulated genes [J].
Kel, A ;
Reymann, S ;
Matys, V ;
Nettesheim, P ;
Wingender, E ;
Borlak, J .
MOLECULAR PHARMACOLOGY, 2004, 66 (06) :1557-1572
[6]  
Lal A, 1999, CANCER RES, V59, P5403
[7]   SAGEmap: A public gene expression resource [J].
Lash, AE ;
Tolstoshev, CM ;
Wagner, L ;
Schuler, GD ;
Strausberg, RL ;
Riggins, GJ ;
Altschul, SF .
GENOME RESEARCH, 2000, 10 (07) :1051-1060
[8]   TRANSFAC®:: transcriptional regulation, from patterns to profiles [J].
Matys, V ;
Fricke, E ;
Geffers, R ;
Gössling, E ;
Haubrock, M ;
Hehl, R ;
Hornischer, K ;
Karas, D ;
Kel, AE ;
Kel-Margoulis, OV ;
Kloos, DU ;
Land, S ;
Lewicki-Potapov, B ;
Michael, H ;
Münch, R ;
Reuter, I ;
Rotert, S ;
Saxel, H ;
Scheer, M ;
Thiele, S ;
Wingender, E .
NUCLEIC ACIDS RESEARCH, 2003, 31 (01) :374-378
[9]  
Michael Holger, 2005, In Silico Biology, V5, P61
[10]   The Eukaryotic Promoter Database EPD [J].
Perier, RC ;
Junier, T ;
Bucher, P .
NUCLEIC ACIDS RESEARCH, 1998, 26 (01) :353-357