DNA replication as a target of the DNA damage checkpoint

被引：99

作者：

Zegerman, Philip ^{[1
]}

Diffley, John F. X. ^{[1
]}

机构：

[1] Clare Hall Labs, Canc Res UK, London Res Inst, S Mimms EN6 3LD, Herts, England

来源：

DNA REPAIR | 2009年 / 8卷 / 09期

关键词：

Rad53; Mec1; Fork stalling; Replication; Origin firing; ATR; Chk1; S-phase; S-PHASE CHECKPOINT; XENOPUS EGG EXTRACTS; ORIGIN RECOGNITION COMPLEX; CELL-CYCLE PROGRESSION; MINICHROMOSOME MAINTENANCE PROTEINS; MAJOR DEVELOPMENTAL TRANSITION; CDK-DEPENDENT PHOSPHORYLATION; RIBONUCLEOTIDE REDUCTASE GENE; EARLY EMBRYONIC LETHALITY; SACCHAROMYCES-CEREVISIAE;

D O I：

10.1016/j.dnarep.2009.04.023

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Faithful inheritance of the genome from mother to daughter cell requires that it is replicated accurately, in its entirety, exactly once. DNA replication not only has to have high fidelity, but also has to cope with exogenous and endogenous agents that damage DNA during the life cycle of a cell. The DNA damage checkpoint, which monitors and responds to defects in the genome, is critical for the completion of replication. The focus of this review is how DNA replication is regulated by the checkpoint response in the presence of DNA damage and fork stalling agents. (C) 2009 Published by Elsevier B.V.

引用

页码：1077 / 1088

页数：12

共 50 条

[21] The ATR-Independent DNA Replication Checkpoint
Brown, Eric J.
CELL CYCLE, 2003, 2 (03) : 188 - 189
[22] DNA damage checkpoint kinases in cancer
Smith, Hannah L.
Southgate, Harriet
Tweddle, Deborah A.
Curtin, Nicola J.
EXPERT REVIEWS IN MOLECULAR MEDICINE, 2020, 22
[23] The Role of Ubiquitination and SUMOylation in DNA Replication
Abbas, Tarek
CURRENT ISSUES IN MOLECULAR BIOLOGY, 2021, 40 : 189 - 220
[24] Initiation of DNA replication in eukaryotic cells
Dutta, A
Bell, SP
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1997, 13 : 293 - 332
[25] Novel DNA damage checkpoint in mitosis: Mitotic DNA damage induces re-replication without cell division in various cancer cells
Hyun, Sun-Yi
Rosen, Eliot M.
Jang, Young-Joo
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2012, 423 (03) : 593 - 599
[26] Checkpoint-Dependent Regulation of Origin Firing and Replication Fork Movement in Response to DNA Damage in Fission Yeast
Kumar, Sanjay
Huberman, Joel A.
MOLECULAR AND CELLULAR BIOLOGY, 2009, 29 (02) : 602 - 611
[27] New Insights into Checkpoint Kinase 1 in the DNA Damage Response Signaling Network
Dai, Yun
Grant, Steven
CLINICAL CANCER RESEARCH, 2010, 16 (02) : 376 - 383
[28] The ATR barrier to replication-born DNA damage
Lopez-Contreras, Andres J.
Fernandez-Capetillo, Oscar
DNA REPAIR, 2010, 9 (12) : 1249 - 1255
[29] Roles of ChlR1 DNA helicase in replication recovery from DNA damage
Shah, Niyant
Inoue, Akira
Lee, Seung Woo
Beishline, Kate
Lahti, Jill M.
Noguchi, Eishi
EXPERIMENTAL CELL RESEARCH, 2013, 319 (14) : 2244 - 2253
[30] A DNA replication fork-centric view of the budding yeast DNA damage response
McClure, Allison W.
Canal, Berta
Diffley, John F. X.
DNA REPAIR, 2022, 119

← 1 2 3 4 5 →