DNA replication as a target of the DNA damage checkpoint

被引：99

作者：

Zegerman, Philip ^{[1
]}

Diffley, John F. X. ^{[1
]}

机构：

[1] Clare Hall Labs, Canc Res UK, London Res Inst, S Mimms EN6 3LD, Herts, England

来源：

DNA REPAIR | 2009年 / 8卷 / 09期

关键词：

Rad53; Mec1; Fork stalling; Replication; Origin firing; ATR; Chk1; S-phase; S-PHASE CHECKPOINT; XENOPUS EGG EXTRACTS; ORIGIN RECOGNITION COMPLEX; CELL-CYCLE PROGRESSION; MINICHROMOSOME MAINTENANCE PROTEINS; MAJOR DEVELOPMENTAL TRANSITION; CDK-DEPENDENT PHOSPHORYLATION; RIBONUCLEOTIDE REDUCTASE GENE; EARLY EMBRYONIC LETHALITY; SACCHAROMYCES-CEREVISIAE;

D O I：

10.1016/j.dnarep.2009.04.023

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Faithful inheritance of the genome from mother to daughter cell requires that it is replicated accurately, in its entirety, exactly once. DNA replication not only has to have high fidelity, but also has to cope with exogenous and endogenous agents that damage DNA during the life cycle of a cell. The DNA damage checkpoint, which monitors and responds to defects in the genome, is critical for the completion of replication. The focus of this review is how DNA replication is regulated by the checkpoint response in the presence of DNA damage and fork stalling agents. (C) 2009 Published by Elsevier B.V.

引用

页码：1077 / 1088

页数：12

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