DNA replication as a target of the DNA damage checkpoint

被引：100
作者：
Zegerman, Philip [1 ]
Diffley, John F. X. [1 ]
机构：
[1] Clare Hall Labs, Canc Res UK, London Res Inst, S Mimms EN6 3LD, Herts, England
来源：
DNA REPAIR | 2009年 / 8卷 / 09期
关键词：
Rad53; Mec1; Fork stalling; Replication; Origin firing; ATR; Chk1; S-phase; S-PHASE CHECKPOINT; XENOPUS EGG EXTRACTS; ORIGIN RECOGNITION COMPLEX; CELL-CYCLE PROGRESSION; MINICHROMOSOME MAINTENANCE PROTEINS; MAJOR DEVELOPMENTAL TRANSITION; CDK-DEPENDENT PHOSPHORYLATION; RIBONUCLEOTIDE REDUCTASE GENE; EARLY EMBRYONIC LETHALITY; SACCHAROMYCES-CEREVISIAE;
D O I：
10.1016/j.dnarep.2009.04.023
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Faithful inheritance of the genome from mother to daughter cell requires that it is replicated accurately, in its entirety, exactly once. DNA replication not only has to have high fidelity, but also has to cope with exogenous and endogenous agents that damage DNA during the life cycle of a cell. The DNA damage checkpoint, which monitors and responds to defects in the genome, is critical for the completion of replication. The focus of this review is how DNA replication is regulated by the checkpoint response in the presence of DNA damage and fork stalling agents. (C) 2009 Published by Elsevier B.V.
引用
收藏
页码：1077 / 1088
页数：12
相关论文
共 241 条
[11]  
Basrai MA, 1999, MOL CELL BIOL, V19, P7041
[12]   DNA replication in eukaryotic cells [J].
Bell, SP ;
Dutta, A .
ANNUAL REVIEW OF BIOCHEMISTRY, 2002, 71 :333-374
[13]   Replication licensing and cancer - a fatal entanglement? [J].
Blow, J. Julian ;
Gillespie, Peter J. .
NATURE REVIEWS CANCER, 2008, 8 (10) :799-806
[14]   Preventing re-replication of chromosomal DNA [J].
Blow, JJ ;
Dutta, A .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (06) :476-486
[15]  
Blumenthal A. B., 1974, COLD SPRING HARB SYM, V38, P205, DOI DOI 10.1101/SQB.1974.038.01.024
[16]   The Cdc7 protein kinase is required for origin firing during S phase [J].
Bousset, K ;
Diffley, JFX .
GENES & DEVELOPMENT, 1998, 12 (04) :480-490
[17]  
Brown EJ, 2000, GENE DEV, V14, P397
[18]   Cell cycle regulation of Dfp1, an activator of the Hsk1 protein kinase [J].
Brown, GW ;
Kelly, TJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (15) :8443-8448
[19]   Purification of Hsk1, a minichromosome maintenance protein kinase from fission yeast [J].
Brown, GW ;
Kelly, TJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (34) :22083-22090
[20]   The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast [J].
Brush, GS ;
Morrow, DM ;
Hieter, P ;
Kelly, TJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (26) :15075-15080
12345678910