DNA replication as a target of the DNA damage checkpoint

被引：99

作者：

Zegerman, Philip ^{[1
]}

Diffley, John F. X. ^{[1
]}

机构：

[1] Clare Hall Labs, Canc Res UK, London Res Inst, S Mimms EN6 3LD, Herts, England

来源：

DNA REPAIR | 2009年 / 8卷 / 09期

关键词：

Rad53; Mec1; Fork stalling; Replication; Origin firing; ATR; Chk1; S-phase; S-PHASE CHECKPOINT; XENOPUS EGG EXTRACTS; ORIGIN RECOGNITION COMPLEX; CELL-CYCLE PROGRESSION; MINICHROMOSOME MAINTENANCE PROTEINS; MAJOR DEVELOPMENTAL TRANSITION; CDK-DEPENDENT PHOSPHORYLATION; RIBONUCLEOTIDE REDUCTASE GENE; EARLY EMBRYONIC LETHALITY; SACCHAROMYCES-CEREVISIAE;

D O I：

10.1016/j.dnarep.2009.04.023

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Faithful inheritance of the genome from mother to daughter cell requires that it is replicated accurately, in its entirety, exactly once. DNA replication not only has to have high fidelity, but also has to cope with exogenous and endogenous agents that damage DNA during the life cycle of a cell. The DNA damage checkpoint, which monitors and responds to defects in the genome, is critical for the completion of replication. The focus of this review is how DNA replication is regulated by the checkpoint response in the presence of DNA damage and fork stalling agents. (C) 2009 Published by Elsevier B.V.

引用

页码：1077 / 1088

页数：12

共 50 条

[1] DNA replication and DNA damage checkpoint control
Tanaka, K
SEIKAGAKU, 2002, 74 (07): : 559 - 563
[2] Activation of the DNA Damage Checkpoint in Mutants Defective in DNA Replication Initiation
Yin, Ling
Locovei, Alexandra Monica
D'Urso, Gennaro
MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (10) : 4374 - 4382
[3] Regulation of DNA replication by the S-phase DNA damage checkpoint
Nicholas Willis
Nicholas Rhind
Cell Division, 4
[4] Regulation of DNA replication by the S-phase DNA damage checkpoint
Willis, Nicholas
Rhind, Nicholas
CELL DIVISION, 2009, 4
[5] Checkpoint Regulation of Replication Forks at Sites of DNA Damage
Iyer, Divya
Rhind, Nick
FASEB JOURNAL, 2015, 29
[6] DNA replication checkpoint
Boddy, MN
Russell, P
CURRENT BIOLOGY, 2001, 11 (23) : R953 - R956
[7] Perspectives on the DNA damage and replication checkpoint responses in Saccharomyces cerevisiae
Putnam, Christopher D.
Jaehnig, Eric J.
Kolodner, Richard D.
DNA REPAIR, 2009, 8 (09) : 974 - 982
[8] Replication-dependent activation of the DNA damage checkpoint.
Byun, TS
Yee, MC
Cimprich, KA
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2004, 228 : U180 - U180
[9] Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks
Segurado, Monica
Diffley, John F. X.
GENES & DEVELOPMENT, 2008, 22 (13) : 1816 - 1827
[10] Replication protein a directs loading of the DNA damage checkpoint clamp to 5′-DNA junctions
Majka, Jerzy
Binz, Sara K.
Wold, Marc S.
Burgers, Peter M. J.
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (38) : 27855 - 27861

← 1 2 3 4 5 →