Determination of penicillins in milk using LC-UV, LC-MS and LC-MS/MS

被引：29

作者：

Martinez-Huelamo, Miriam ^{[1
]}

Jimenez-Gamez, Esther ^{[1
]}

Pilar Hermo, Maria ^{[1
]}

Barron, Dolores ^{[1
]}

Barbosa, Jose ^{[1
]}

机构：

[1] Univ Barcelona, Dept Analyt Chem, E-08028 Barcelona, Spain

来源：

JOURNAL OF SEPARATION SCIENCE | 2009年 / 32卷 / 14期

关键词：

LC; Milk; MS; Penicillins; SPE; TANDEM MASS-SPECTROMETRY; BETA-LACTAM ANTIBIOTICS; SOLID-PHASE EXTRACTION; LIQUID-CHROMATOGRAPHY; VETERINARY DRUGS; RESIDUE ANALYSIS; ANIMAL ORIGIN; FOOD-PRODUCTS; BOVINE-MILK; CONFIRMATION;

D O I：

10.1002/jssc.200900212

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The aim of this work is to establish a method for the simultaneous determination of eight penicillins in milk samples by LC-UV, LC-MS and LC-MS/MS. The procedure involves a step for clean-up and to preconcentrate the analytes by SPE and a subsequent chromatographic analysis. LC-UV, LG-MS and LC-MS/MS have been used for the simultaneous quantification of penicillins in milk. The proposed methods have been validated according to the EU guideline and present LOQ below the maximum limits of residues (MRLs) established by the European Union for penicillins in milk. The developed methods were applied to different milk samples obtained from cows medicated with penicillins.

引用

页码：2385 / 2393

页数：9

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